2LK1: RNA-binding protein 5

Solution structure and binding studies of the RanBP2-type zinc finger of RBM5. Determined by solution NMR. Released 28 Dec 2011.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 281
Mol. weight: 4.09 kDa
Ligands: ZN, AQN
Released: 28 Dec 2011

Explore 2LK1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LK1 contains 0 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	1
β-strand	13-14	2	1
β-strand	20	1	2
β-strand	27	1	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RNA-binding protein 5	A	protein	32	Homo sapiens	P52756 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2LK1_1 RNA-binding protein 5 (chains A)
XKFEDWLCNKCCLNNFRKRLKCFRCGADKFDX

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1
AQN	9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	C14 H8 O5 S	1

Primary citation

Targeting Zinc Finger Domains with Small Molecules: Solution Structure and Binding Studies of the RanBP2-Type Zinc Finger of RBM5. Farina, B., Fattorusso, R., Pellecchia, M. Chembiochem (2011) 12:2837-2845. DOI 10.1002/cbic.201100582 · PubMed

Other PDB entries of the same protein (UniProt P52756 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7PCV 2.42 Å, Crystal structure of RBM5 RRM1-zinc finger
9ZE2 3.26 Å, Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (core)
9ZE0 3.43 Å, Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (Proximal DHX15…
7PDV 3.49 Å, Crystal structure of RBM5 RRM1-zinc finger in complex with RNA
9ZEC 3.61 Å, Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (SF3A state 1)
9ZE3 3.93 Å, Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (Distal DHX15…
9ZED 3.94 Å, Cryo-EM structure of the endogenous U2/branchpoint spliceosomal complex (SF3A state 2)
2LK0 Solution structure and binding studies of the RanBP2-type zinc finger of RBM5
2LKZ Solution structure of the second RRM domain of RBM5
5MF9 Solution structure of the RBM5 OCRE domain in complex with polyproline SmN peptide.
5MFY RBM5 OCRE domain

Browse structure collections

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