2LTZ: Smurf2 WW3 domain

Smurf2 WW3 domain in complex with a Smad7 derived peptide. Determined by solution NMR. Released 21 Nov 2012.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 423
Mol. weight: 5.98 kDa
Released: 21 Nov 2012

Explore 2LTZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LTZ contains 1 α-helix and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	303-308	6	1
β-strand	312-317	6	1
β-strand	322-324	3	1

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	207-210	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase SMURF2	A	protein	37	Homo sapiens	Q9HAU4 (AlphaFold model)
Smad7 derived peptide	B	protein	15	Homo sapiens	O15105 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2LTZ_1 E3 ubiquitin-protein ligase SMURF2 (chains A)
GPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSAN

Sequence of entity 2 (B), FASTA

>2LTZ_2 Smad7 derived peptide (chains B)
ELESPPPPYSRYPMD

Primary citation

Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways. Aragon, E., Goerner, N., Xi, Q. et al. Structure (2012) 20:1726-1736. DOI 10.1016/j.str.2012.07.014 · PubMed

Other PDB entries of the same protein (UniProt Q9HAU4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9FSH 2.08 Å, Crystal structure of the HECT domain of Smurf 2 in complex with inhibitor 8
1ZVD 2.1 Å, Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain
6FX4 2.5 Å, Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
7M3Q 2.5 Å, Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
2DJY Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex
2JQZ Solution Structure of the C2 domain of human Smurf2
2KXQ Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide

Browse structure collections

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