2MPM: Eotaxin

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal Region of CCR3 Bound to CCL11/Eotaxin-1. Determined by solution NMR. Released 10 Dec 2014.

Method: Solution NMR
Organisms: Homo sapiens, HOMO SAPIENS
Chains: 2
Atoms: 719
Mol. weight: 10.32 kDa
Released: 10 Dec 2014

Explore 2MPM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MPM contains 1 α-helix and 5 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 5 β-strands

Element	Residues	Length	Sheet
β-strand	25	1	1
β-strand	28	1	2
β-strand	39-41	3	2
β-strand	42	1	1
β-strand	49-51	3	2
α-helix	56-67	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eotaxin	A	protein	74	Homo sapiens	P51671 (AlphaFold model)
CCR3	B	protein	16	HOMO SAPIENS

Sequence of entity 1 (A), FASTA

>2MPM_1 Eotaxin (chains A)
GPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQD
SMKYLDQKSPTPKP

Sequence of entity 2 (B), FASTA

>2MPM_2 CCR3 (chains B)
VETFGTTSYYDDVGLL

Primary citation

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1. Millard, C.J., Ludeman, J.P., Canals, M. et al. Structure (2014) 22:1571-1581. DOI 10.1016/j.str.2014.08.023 · PubMed

Other PDB entries of the same protein (UniProt P51671 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SCS 1.51 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11
1EOT Solution NMR structure of eotaxin, minimized average structure
2EOT Solution structure of eotaxin, an ensemble of 32 NMR solution structures

Browse structure collections

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