2N2F: Dynorphin 1-13

Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor. Determined by solution NMR. Released 9 Sept 2015.

Method

Solution NMR

Organism

Homo sapiens

Chains

1

Atoms

114

Mol. weight

1.61 kDa

Released

9 Sept 2015

Explore 2N2F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2N2F contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Molecules and chains

>2N2F_1 Dynorphin A(1-13) (chains A)
YGGFLRRIRPKLK

Primary citation

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. O'Connor, C., White, K.L., Doncescu, N. et al. Proc Natl Acad Sci U S A (2015) 112:11852-11857. DOI 10.1073/pnas.1510117112 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P01213 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 8VJU 1.99 Å, Structure of Human Neurolysin in complex with dynorphin A13 peptide
• 8VJV 2.12 Å, Structure of Human Neurolysin in complex with dynorphin A8(1-8) peptide
• 9L60 2.9 Å, Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric…
• 9CCE 3.15 Å, structure of DYNA_1b7
• 8F7W 3.19 Å, Gi bound kappa-opioid receptor in complex with dynorphin
• 7Y1F 3.3 Å, Cryo-EM structure of human k-opioid receptor-Gi complex
• 9CCF 4.0 Å, Crystal Structure of DA7-2

Browse structure collections

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