Inner centromere protein (INCENP) is a 918-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NQS7.
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The mean pLDDT of this model is 59.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The…
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex binds directly to AURKB or AURKC via the IN box, and forms a triple-helix bundle-based subcomplex with BIRC5 and CDCA8 via its N-terminus (PubMed:17956729, PubMed:27332895). The reported homodimerization is questioned as the SAH domain is shown to be…
Nucleus, Chromosome, centromere, Cytoplasm, cytoskeleton, spindle, Midbody, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QFA | X-ray | 1.4 Å | C=1-47 |
| 5IEH | X-ray | 1.5 Å | C=47-55 |
| 6GR8 | X-ray | 1.75 Å | B=835-903 |
| 5IEK | X-ray | 1.8 Å | C=47-55 |
| 6YIF | X-ray | 1.81 Å | C=7-57 |
| 6GR9 | X-ray | 2.25 Å | B=835-903 |
| 8RUP | EM | 2.42 Å | M=1-80 |
| 6YIH | X-ray | 2.55 Å | C=5-80 |
| 4AF3 | X-ray | 2.75 Å | D=835-903 |
| 9ESA | X-ray | 2.8 Å | CCC/DDD=834-891 |
| 9SI3 | EM | 2.83 Å | N=1-918 |
| 9SJ5 | EM | 2.85 Å | N=1-918 |
| 9SI9 | EM | 2.86 Å | N=1-918 |
| 9N9F | EM | 2.91 Å | S=1-918 |
| 6YIE | X-ray | 3.49 Å | C/F=1-58 |
| 9SLJ | EM | 3.8 Å | N/Q=1-918 |
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