Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution. Determined by X-ray diffraction at 3.8 Å resolution. Released 25 Dec 2007.
Explore 2R69 in 3D Show helices and sheets RCSB PDB PDBe
2R69 contains 7 α-helices and 55 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 300 | 1 | |
| β-strand | 301 | 1 | 1 |
| α-helix | 302 | 1 | |
| β-strand | 305-308 | 4 | 2 |
| α-helix | 311-313 | 3 | |
| β-strand | 320 | 1 | 3 |
| β-strand | 323-327 | 5 | 2 |
| β-strand | 334 | 1 | 1 |
| β-strand | 338-340 | 3 | 4 |
| β-strand | 341 | 1 | 5 |
| β-strand | 345 | 1 | 5 |
| β-strand | 350-351 | 2 | 3 |
| β-strand | 365-366 | 2 | 2 |
| β-strand | 369-370 | 2 | 3 |
| β-strand | 375-379 | 5 | 4 |
| β-strand | 389-392 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-6 | 2 | 6 |
| β-strand | 10-12 | 3 | 7 |
| β-strand | 21-23 | 3 | 6 |
| α-helix | 29-31 | 3 | |
| β-strand | 34-39 | 6 | 8 |
| β-strand | 46-51 | 6 | 8 |
| β-strand | 60 | 1 | 8 |
| α-helix | 62-64 | 3 | |
| β-strand | 71 | 1 | 6 |
| β-strand | 79-80 | 2 | 6 |
| β-strand | 93-95 | 3 | 8 |
| β-strand | 112-114 | 3 | 7 |
| β-strand | 123-127 | 5 | 9 |
| β-strand | 142-146 | 5 | 9 |
| β-strand | 154-156 | 3 | 10 |
| β-strand | 166-168 | 3 | 9 |
| α-helix | 169-171 | 3 | |
| β-strand | 172-174 | 3 | 9 |
| β-strand | 177-184 | 8 | 9 |
| β-strand | 199-202 | 4 | 10 |
| β-strand | 207-209 | 3 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4 | 1 | 11 |
| β-strand | 10 | 1 | 12 |
| β-strand | 13 | 1 | 13 |
| β-strand | 19-21 | 3 | 14 |
| β-strand | 24 | 1 | 15 |
| β-strand | 25 | 1 | 11 |
| β-strand | 37-41 | 5 | 16 |
| β-strand | 49-53 | 5 | 16 |
| β-strand | 70 | 1 | 17 |
| β-strand | 74 | 1 | 15 |
| β-strand | 75 | 1 | 17 |
| β-strand | 77-79 | 3 | 14 |
| β-strand | 89 | 1 | 12 |
| α-helix | 90-91 | 2 | |
| β-strand | 92-94 | 3 | 16 |
| β-strand | 107 | 1 | 12 |
| β-strand | 110 | 1 | 13 |
| β-strand | 120 | 1 | 18 |
| β-strand | 138-143 | 6 | 18 |
| β-strand | 151-152 | 2 | 19 |
| β-strand | 164 | 1 | 20 |
| β-strand | 167-171 | 5 | 18 |
| β-strand | 176-181 | 6 | 18 |
| β-strand | 182 | 1 | 20 |
| β-strand | 198-199 | 2 | 19 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Major envelope protein E | A | protein | 97 | Dengue virus 2 Thailand/16681/84 | P29990 |
| Heavy chain of 1A1D-2 | H | protein | 214 | Mus musculus | P01863 (AlphaFold model) |
| Light chain of 1A1D-2 | L | protein | 212 | Mus musculus | P01660 (AlphaFold model) |
>2R69_1 Major envelope protein E (chains A) SYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPI VTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKK
>2R69_2 Heavy chain of 1A1D-2 (chains H) EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPANGYSKY DPKFQGKATITADTSSNAAYLQLSSLTSEDTAVYFCARDYEGFAYWGQGTLVTVSSAKTT PPSVYPLAPGAATSSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSS SVTVTSSTWPSQTITCNVAHPASSTKVDKKIEPR
>2R69_3 Light chain of 1A1D-2 (chains L) DIVLTQSPASLAVSLGQRATISCRASESVVRYGNSFMHWYQQKPGQPPKLLIYRASSLES GIPTRFSGSGSRTDFTLTINPVEADDVATYYCQQTNVDPWAFGGGTKLEIKRADAAPTVS IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMS STLTLTKDEYERHNSYTCEATSPIVKSFNRNE
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Lok, S.M., Kostyuchenko, V., Nybakken, G.E. et al. Nat Struct Mol Biol (2008) 15:312-317. DOI 10.1038/nsmb.1382 · PubMed
Other PDB entries of the same protein (UniProt P29990), best resolution first:
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