2RAW: Borealin-Survivin complex

Crystal structure of the Borealin-Survivin complex. Determined by X-ray diffraction at 2.4 Å resolution. Released 30 Oct 2007.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,598
Mol. weight: 25.03 kDa
Ligands: ZN
Released: 30 Oct 2007

Explore 2RAW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2RAW contains 9 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
α-helix	15-19	5
α-helix	35-41	7
β-strand	43-45	3	1
β-strand	55-57	3	1
β-strand	63-64	2	1
α-helix	73-80	8
α-helix	85-88	4
β-strand	97	1	2
α-helix	98-139	42

Chain B: 3 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	24-59	36
α-helix	63-66	4
β-strand	69	1	2
α-helix	70-74	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral IAP repeat-containing protein 5	A	protein	145	Homo sapiens	O15392 (AlphaFold model)
Borealin	B	protein	68	Homo sapiens	Q53HL2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2RAW_1 Baculoviral IAP repeat-containing protein 5 (chains A)
GSHMGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQC
FFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKET
NNKKKEFEETAKKVRRAIEQLAAMD

Sequence of entity 2 (B), FASTA

>2RAW_2 Borealin (chains B)
MKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFALGG
WSHPQFEK

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin. Bourhis, E., Hymowitz, S.G., Cochran, A.G. J Biol Chem (2007) 282:35018-35023. DOI 10.1074/jbc.M706233200 · PubMed

Other PDB entries of the same protein (UniProt O15392 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2QFA 1.4 Å, Crystal structure of a Survivin-Borealin-INCENP core complex
9TPI 1.8 Å, Survivin 1-122 in complex with a molecular tweezer-Histone-H3-peptide conjugate
6YIF 1.81 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
9TPH 2.0 Å, Survivin 1-127 in complex with a molecular tweezer-Histone-H3-peptide conjugate
3UEC 2.18 Å, Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
3UIG 2.4 Å, crystal structure of human Survivin in complex with T3 phosphorylated H3(1-15) peptide
3UIH 2.4 Å, crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide
8RUP 2.42 Å, Chromosome Passenger Complex (CPC) localization module in complex with H3.T3p-nucleosome
3UEF 2.45 Å, Crystal structure of human Survivin bound to histone H3 (C2 space group).
7LBO 2.5 Å, Crystal structure of human Survivin bound to histone H3 T3phK4me1 peptide
6YIH 2.55 Å, Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3…
1F3H 2.58 Å, X-ray crystal structure of the human anti-apoptotic protein survivin

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