2RCJ: Human Immunoglobulin M

Solution structure of human Immunoglobulin M. Determined by solution scattering. Released 22 Jan 2008.

Method
Solution scattering
Organism
Homo sapiens
Chains
21
Atoms
7,514
Mol. weight
809.95 kDa
Released
22 Jan 2008

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Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
IgA1 light chainA, B, E, F, I, J, M, N, Q, Rprotein218Homo sapiensP01857 (AlphaFold model)
IgA1 heavy chainC, D, G, H, K, L, O, P, S, Tprotein523Homo sapiensP0DOX5 (AlphaFold model)
J chainUprotein104Homo sapiensP0DOX5 (AlphaFold model)
Sequence of entity 1 (A, B, E, F, I, J, M, N, Q, R), FASTA
>2RCJ_1 IgA1 light chain (chains A, B, E, F, I, J, M, N, Q, R)
EVQLVQSGGGVVQPGRSLRLSCSSSGFIFSSYAMYWVRQAPGKGLEWVAIIWDDGSDQHY
ADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCARDGGSSAPDYWGQGTPVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGL
YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP
Sequence of entity 2 (C, D, G, H, K, L, O, P, S, T), FASTA
>2RCJ_2 IgA1 heavy chain (chains C, D, G, H, K, L, O, P, S, T)
ESVLTQPPSASGTPGQRVTISCTGTSSGSITVNWYQQLPGMAPKLLIYRDAMRPSGVPTR
FSGSKSGTSASLAISGLEAEDESDYYCASWNSSDNSYVFGTGTKVTVLGQPKANPTVTLF
PPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYL
SLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECSASTKGPSVFPLAPSSKSTSGGTAALG
CLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN
HKPSNTKVDKRVEPLSLPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWYVD
GVQVHNAKTKPREQQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISKAK
GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS
DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
Sequence of entity 3 (U), FASTA
>2RCJ_3 J chain (chains U)
SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQS
SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC

Primary citation

Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation. Perkins, S.J., Nealis, A.S., Sutton, B.J. et al. J Mol Biol (1991) 221:1345-1366. DOI 10.1016/0022-2836(91)90937-2 · PubMed

Other PDB entries of the same protein (UniProt P01857 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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