2RFO: Crystral Structure of the nucleoporin Nic96

Crystral Structure of the nucleoporin Nic96. Determined by X-ray diffraction at 2.6 Å resolution. Released 29 Jan 2008.

Method

X-ray diffraction

Resolution

2.6 Å

Organism

Saccharomyces cerevisiae

Chains

2

Atoms

9,984

Mol. weight

149.64 kDa

Released

29 Jan 2008

Explore 2RFO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2RFO contains 73 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 5 β-strands

Molecules and chains

>2RFO_1 Nucleoporin NIC96 (chains A, B)
GNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFISILSSANGT
RNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLATNVNKIKSF
IDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFL
TYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAV
TLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQTLLLSGLY
GLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILANYTKSFRYS
DPRVAVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQ
PLLHVRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSLLSDTLSAS
DLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNISSIRELYF
NKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHI
LNESKYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL

Primary citation

Structural basis of the nic96 subcomplex organization in the nuclear pore channel. Schrader, N., Stelter, P., Flemming, D. et al. Mol Cell (2008) 29:46-55. DOI 10.1016/j.molcel.2007.10.022 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P34077 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6X07 2.1 Å, Nic96 from S. cerevisiae bound by VHH-SAN12
• 2QX5 2.5 Å, Structure of nucleoporin Nic96
• 7WOO 3.71 Å, Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear…
• 7WOT 3.73 Å, Cryo-EM structure of the inner ring monomer of the Saccharomyces cerevisiae nuclear pore…
• 8TJ5 6.6 Å, Inner spoke ring of the yeast NPC
• 7N85 7.6 Å, Inner ring spoke from the isolated yeast NPC
• 7N9F 37.0 Å, Structure of the in situ yeast NPC
• 8ZZA Integrative structure and functional anatomy of a single spoke of a nuclear pore complex
• 8ZZB Integrative structure and functional anatomy of three spokes of a nuclear pore complex
• 8ZZC Integrative structure and functional anatomy of eight spokes of a nuclear pore complex
• 9A0F Integrative model of the wild type yeast nuclear pore complex
• 9A0G Integrative model of Nup116 knockout (at 25C) yeast nuclear pore complex

Browse structure collections

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