2RJW: H41Y mutant of villin headpiece, P61 SPACE GROUP

The crystal structure of the H41Y mutant of villin headpiece, P61 SPACE GROUP. Determined by X-ray diffraction at 1.55 Å resolution. Released 17 Feb 2009.

Method: X-ray diffraction
Resolution: 1.55 Å
Organism: Gallus gallus
Chains: 2
Atoms: 1,252
Mol. weight: 15.27 kDa
Released: 17 Feb 2009

Explore 2RJW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2RJW contains 15 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	11-15	5
α-helix	18-23	6
α-helix	26-28	3
α-helix	30	1
α-helix	38-41	4
α-helix	44-51	8
α-helix	55-60	6
α-helix	63-71	9

Chain B: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	18-21	4
α-helix	26-28	3
α-helix	30	1
α-helix	35-41	7
α-helix	44-51	8
α-helix	55-58	4
α-helix	63-72	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Villin-1	A, B	protein	67	Gallus gallus	P02640 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2RJW_1 Villin-1 (chains A, B)
PTKLETFPLDVLVNTAAEDLPRGVDPSRKENYLSDEDFKAVFGMTRSAFANLPLWKQQNL
KKEKGLF

Primary citation

Heterogeneity and dynamics in villin headpiece crystal structures. Meng, J., McKnight, C.J. Acta Crystallogr D Biol Crystallogr (2009) 65:470-476. DOI 10.1107/S0907444909008646 · PubMed

Other PDB entries of the same protein (UniProt P02640 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1WY3 0.95 Å, Chicken villin subdomain HP-35, K65(NLE), N68H, pH7.0
1YRI 1.0 Å, Chicken villin subdomain HP-35, N68H, pH6.4
3TRV 1.0 Å, Crystal structure of quasiracemic villin headpiece subdomain containing (F5Phe17)…
2F4K 1.05 Å, Chicken villin subdomain HP-35, K65(NLE), N68H, K70(NLE), PH9
1YRF 1.07 Å, Chicken villin subdomain HP-35, N68H, pH6.7
5I1S 1.12 Å, Villin headpiece subdomain with a Lys30 to APC substitution
5I1N 1.3 Å, Villin headpiece subdomain with a Gln26 to beta-3-homoglutamine substitution
5I1O 1.35 Å, Villin headpiece subdomain with a Gln26 to ACPC substitution
1YU5 1.4 Å, Crystal Structure of the Headpiece Domain of Chicken Villin
2RJY 1.4 Å, Crystal structure of villin headpiece, P21 21 21 space group
5I1P 1.4 Å, Villin headpiece subdomain with a Lys30 to beta-3-homolysine substitution
1YU8 1.45 Å, Crystal Structure of the R37A Mutant of Villin Headpiece

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