2RR9: K63-Ub2:tUIMs complex

The solution structure of the K63-Ub2:tUIMs complex. Determined by solution NMR. Released 6 Jul 2011.

Method: Solution NMR
Organism: Homo sapiens
Chains: 3
Atoms: 1,572
Mol. weight: 22.47 kDa
Released: 6 Jul 2011

Explore 2RR9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2RR9 contains 7 α-helices and 14 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	1
β-strand	12-16	5	1
β-strand	22	1	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	42-45	4	1
β-strand	48-49	2	1
β-strand	55	1	2
α-helix	56-59	4
β-strand	66-70	5	1

Chain B: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	3
β-strand	12-16	5	3
β-strand	22	1	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	42-45	4	3
β-strand	48-49	2	3
α-helix	50	1
β-strand	55	1	4
β-strand	66-70	5	3

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	82-119	38

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ubiquitin	A, B	protein	76	Homo sapiens	P0CG48 (AlphaFold model)
Putative uncharacterized protein UIMC1	C	protein	46	Homo sapiens	Q96RL1 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2RR9_1 ubiquitin (chains A, B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Sequence of entity 2 (C), FASTA

>2RR9_2 Putative uncharacterized protein UIMC1 (chains C)
MTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPS

Primary citation

The solution structure of the K63-Ub2:tUIMs complex. Sekiyama, N., Jee, J., Isogai, S. et al. To be published.

Other PDB entries of the same protein (UniProt P0CG48 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6Q00 0.85 Å, TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1
1OGW 1.32 Å, Synthetic Ubiquitin with fluoro-Leu at 50 and 67
5NL4 1.32 Å, Crystal structure of Zn1.3-E16V human ubiquitin (hUb) mutant adduct, from a solution 35…
2GBJ 1.35 Å, Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin.
4HK2 1.4 Å, U7Ub25.2540
9FJ3 1.4 Å, Structure of ubiquitin bound of coiled-coil UIM form 2
1XD3 1.45 Å, Crystal structure of UCHL3-UbVME complex
4IUM 1.45 Å, Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin
7UV5 1.45 Å, The crystal structure of Papain-Like Protease of SARS CoV-2, C111S/D286N mutant, in…
5NLF 1.5 Å, Crystal structure of Zn2.7-E16V human ubiquitin (hUb) mutant adduct, from a solution 100…
9F6G 1.5 Å, Human USP30 chimera bound to Ubiquitin-PA
9OVX 1.5 Å, Crystal structure of ubiquitin K27M mutant

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