2V8Y: Eukaryotic translation initiation factor 4E

Name: PDB 2V8Y: Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
Published: 2007-08-28
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: translation

Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives. Determined by X-ray diffraction at 2.1 Å resolution. Released 28 Aug 2007.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 3,622
Mol. weight: 54.93 kDa
Ligands: MGV
Released: 28 Aug 2007

Explore 2V8Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2V8Y contains 22 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	1
α-helix	57-59	3
β-strand	60-68	9	1
α-helix	69-76	8
α-helix	82-84	3
α-helix	86	1
β-strand	89-95	7	1
β-strand	111-116	6	1
α-helix	119-124	6
α-helix	126-138	13
α-helix	143-148	6
β-strand	149-155	7	1
β-strand	162-167	6	1
α-helix	173-187	15
β-strand	196-199	4	1
α-helix	200-203	4
β-strand	215-216	2	1

Chains B and F: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	56-61	6

Chain E: 11 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	36-37	2
β-strand	38-48	11	2
α-helix	57-59	3
β-strand	60-68	9	2
α-helix	69-78	10
α-helix	80-81	2
α-helix	82-84	3
α-helix	86	1
β-strand	90-95	6	2
β-strand	111-117	7	2
α-helix	118-119	2
α-helix	125-138	14
α-helix	143-148	6
β-strand	149-156	8	2
β-strand	161-167	7	2
α-helix	173-186	14
β-strand	196-199	4	2
α-helix	200-202	3
β-strand	215-216	2	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eukaryotic translation initiation factor 4E	A, E	protein	217	HOMO SAPIENS	P06730 (AlphaFold model)
Eukaryotic translation initiation factor 4E-binding protein 1	B, F	protein	14	HOMO SAPIENS	Q13541 (AlphaFold model)

Sequence of entity 1 (A, E), FASTA

>2V8Y_1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (chains A, E)
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

Sequence of entity 2 (B, F), FASTA

>2V8Y_2 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 (chains B, F)
RIIYDRKFLMECRN

Ligands and cofactors

ID	Name	Formula	Copies
MGV	P-fluoro-7-benzyl guanine monophosphate	C17 H20 F N5 O8 P	2

Primary citation

Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives. Brown, C.J., Mcnae, I., Fischer, P.M. et al. J Mol Biol (2007) 372:7. DOI 10.1016/J.JMB.2007.06.033 · PubMed

Other PDB entries of the same protein (UniProt P06730 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4TPW 1.5 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5T46 1.53 Å, Crystal structure of the human eIF4E-eIF4G complex
8QM8 1.58 Å, Potential drug binding sites for translation initiation factor eIF4E
4TQB 1.59 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5ZJY 1.59 Å, Stapled-peptides tailored against initiation of translation
7D6Y 1.67 Å, eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
5ZJZ 1.67 Å, Stapled-peptides tailored against initiation of translation
5EI3 1.71 Å, Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
4UED 1.75 Å, Complex of human eIF4E with the 4E binding protein 4E-BP1
5ZK9 1.76 Å, Stapled-peptides tailored against initiation of translation
4TQC 1.8 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5ZML 1.8 Å, Stapled-peptides tailored against initiation of translation

Browse structure collections

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