The Structural Dynamics and Energetics of an Immunodominant T-cell Receptor are Programmed by its Vbeta Domain. Determined by X-ray diffraction at 1.98 Å resolution. Released 22 Jan 2008.
Explore 2VLM in 3D Show helices and sheets RCSB PDB PDBe
2VLM contains 10 α-helices and 42 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-8 | 4 | 1 |
| β-strand | 11-15 | 5 | 2 |
| β-strand | 20-26 | 7 | 1 |
| β-strand | 32-38 | 7 | 2 |
| β-strand | 45-50 | 6 | 2 |
| β-strand | 56-59 | 4 | 1 |
| β-strand | 62-66 | 5 | 1 |
| β-strand | 72-77 | 6 | 1 |
| α-helix | 82-84 | 3 | |
| β-strand | 86-93 | 8 | 2 |
| β-strand | 100-101 | 2 | 2 |
| β-strand | 105-110 | 6 | 2 |
| α-helix | 111-112 | 2 | |
| β-strand | 119-125 | 7 | 3 |
| β-strand | 132-137 | 6 | 3 |
| β-strand | 154-156 | 3 | 3 |
| β-strand | 172-176 | 5 | 3 |
| α-helix | 184-187 | 4 | |
| β-strand | 198 | 1 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 6-9 | 4 | 4 |
| β-strand | 12-16 | 5 | 5 |
| β-strand | 21-23 | 3 | 6 |
| β-strand | 24-27 | 4 | 4 |
| β-strand | 33-40 | 8 | 5 |
| β-strand | 44-51 | 8 | 5 |
| β-strand | 58-59 | 2 | 5 |
| β-strand | 66-68 | 3 | 6 |
| β-strand | 75 | 1 | 4 |
| β-strand | 78-80 | 3 | 6 |
| α-helix | 81 | 1 | |
| β-strand | 89-96 | 8 | 5 |
| β-strand | 104-105 | 2 | 5 |
| β-strand | 109-114 | 6 | 5 |
| α-helix | 117-119 | 3 | |
| β-strand | 121 | 1 | 7 |
| α-helix | 122-123 | 2 | |
| β-strand | 124-129 | 6 | 3 |
| α-helix | 130-131 | 2 | |
| α-helix | 132-138 | 7 | |
| β-strand | 140-150 | 11 | 3 |
| β-strand | 151 | 1 | 7 |
| β-strand | 155-161 | 7 | 8 |
| β-strand | 164-166 | 3 | 8 |
| β-strand | 170-172 | 3 | 3 |
| β-strand | 177-178 | 2 | 3 |
| β-strand | 188-197 | 10 | 3 |
| α-helix | 198-201 | 4 | |
| β-strand | 207-214 | 8 | 8 |
| β-strand | 217 | 1 | 9 |
| α-helix | 228-229 | 2 | |
| β-strand | 231 | 1 | 9 |
| β-strand | 233-240 | 8 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| JM22 TCR alpha chain | D | protein | 201 | HOMO SAPIENS | P01848 (AlphaFold model) |
| JM22 TCR beta chain | E | protein | 244 | HOMO SAPIENS | P01850 (AlphaFold model) |
>2VLM_1 JM22 TCR ALPHA CHAIN (chains D) MQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKR LTFQFGDARKDSSLHITAAQPGDTGLYLCAGAGSQGNLIFGKGTKLSVKPNIQNPDPAVY QLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSD FACANAFNNSIIPEDTFFPSK
>2VLM_2 JM22 TCR BETA CHAIN (chains E) MVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKG DIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNV FPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQ PALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAW GRAD
The Structural Dynamics and Energetics of an Immunodominant T-Cell Receptor are Programmed by its Vbeta Domain. Ishizuka, J., Stewart-Jones, G., Van Der Merwe, A. et al. Immunity (2008) 28:171. DOI 10.1016/J.IMMUNI.2007.12.018 · PubMed
Other PDB entries of the same protein (UniProt P01848 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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