2VOI: Mouse A1

Structure of mouse A1 bound to the Bid BH3-domain. Determined by X-ray diffraction at 2.1 Å resolution. Released 4 Mar 2008.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: MUS MUSCULUS
Chains: 2
Atoms: 1,407
Mol. weight: 21.9 kDa
Released: 4 Mar 2008

Explore 2VOI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2VOI contains 10 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	1-20	20
α-helix	29-31	3
α-helix	32-51	20
α-helix	53-56	4
α-helix	64-78	15
α-helix	86-106	21
α-helix	114-136	23
α-helix	139-144	6
α-helix	145-147	3

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	79-99	21

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bcl-2-related protein A1	A	protein	157	MUS MUSCULUS	Q07440 (AlphaFold model)
BH3-interacting domain death agonist P13	B	protein	34	MUS MUSCULUS	P70444 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2VOI_1 BCL-2-RELATED PROTEIN A1 (chains A)
GPLGSMAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSY
LDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLKQEQIALDVSAY
KQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKS

Sequence of entity 2 (B), FASTA

>2VOI_2 BH3-INTERACTING DOMAIN DEATH AGONIST P13 (chains B)
SESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQL

Primary citation

Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Smits, C., Czabotar, P.E., Hinds, M.G. et al. Structure (2008) 16:818. DOI 10.1016/J.STR.2008.02.009 · PubMed

Other PDB entries of the same protein (UniProt Q07440 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2VOF 1.8 Å, Structure of mouse A1 bound to the Puma BH3-domain
2VOG 1.9 Å, Structure of mouse A1 bound to the Bmf BH3-domain
2VOH 1.9 Å, Structure of mouse A1 bound to the Bak BH3-domain

Browse structure collections

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