HCV-H77 NS5B Polymerase Complexed With GTP. Determined by X-ray diffraction at 1.7 Å resolution. Released 4 Aug 2010.
Explore 2XI3 in 3D Show helices and sheets RCSB PDB PDBe
2XI3 contains 86 α-helices and 57 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 1 |
| β-strand | 4-6 | 3 | 2 |
| α-helix | 9-11 | 3 | |
| β-strand | 20 | 1 | 3 |
| α-helix | 21-23 | 3 | |
| α-helix | 25-30 | 6 | |
| α-helix | 34-36 | 3 | |
| β-strand | 37-39 | 3 | 3 |
| α-helix | 42-44 | 3 | |
| α-helix | 45-52 | 8 | |
| β-strand | 55 | 1 | 1 |
| α-helix | 62-75 | 14 | |
| β-strand | 79 | 1 | 4 |
| α-helix | 82-84 | 3 | |
| α-helix | 85-90 | 6 | |
| α-helix | 97-99 | 3 | |
| α-helix | 105-109 | 5 | |
| α-helix | 113-128 | 16 | |
| α-helix | 133-135 | 3 | |
| β-strand | 136-140 | 5 | 2 |
| β-strand | 144-146 | 3 | 3 |
| β-strand | 148 | 1 | 5 |
| α-helix | 149-151 | 3 | |
| β-strand | 153 | 1 | 5 |
| α-helix | 155-158 | 4 | |
| β-strand | 159-162 | 4 | 2 |
| α-helix | 165-187 | 23 | |
| α-helix | 188-190 | 3 | |
| β-strand | 191 | 1 | 6 |
| α-helix | 192-194 | 3 | |
| α-helix | 197-209 | 13 | |
| β-strand | 214-219 | 6 | 6 |
| β-strand | 221 | 1 | 7 |
| α-helix | 224-227 | 4 | |
| α-helix | 230-240 | 11 | |
| β-strand | 244 | 1 | 4 |
| α-helix | 247-256 | 10 | |
| α-helix | 257-261 | 5 | |
| β-strand | 264-267 | 4 | 2 |
| β-strand | 273-277 | 5 | 2 |
| α-helix | 287-306 | 20 | |
| β-strand | 309-316 | 8 | 6 |
| β-strand | 319-325 | 7 | 6 |
| α-helix | 329-345 | 17 | |
| β-strand | 350 | 1 | 7 |
| β-strand | 357 | 1 | 6 |
| α-helix | 360-362 | 3 | |
| β-strand | 365 | 1 | 8 |
| β-strand | 368-374 | 7 | 8 |
| β-strand | 380-386 | 7 | 8 |
| α-helix | 389-400 | 12 | |
| α-helix | 407-415 | 9 | |
| α-helix | 419-420 | 2 | |
| α-helix | 421-426 | 6 | |
| α-helix | 427-435 | 9 | |
| β-strand | 443-447 | 5 | 9 |
| β-strand | 450-454 | 5 | 9 |
| α-helix | 456-458 | 3 | |
| α-helix | 459-467 | 9 | |
| α-helix | 469-472 | 4 | |
| β-strand | 475 | 1 | 8 |
| α-helix | 479-492 | 14 | |
| α-helix | 494-496 | 3 | |
| α-helix | 497-514 | 18 | |
| α-helix | 516-520 | 5 | |
| α-helix | 521-525 | 5 | |
| α-helix | 527-529 | 3 | |
| α-helix | 533-535 | 3 | |
| α-helix | 537-539 | 3 | |
| α-helix | 540-544 | 5 | |
| β-strand | 561 | 1 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 10 |
| β-strand | 4-6 | 3 | 11 |
| α-helix | 9-11 | 3 | |
| β-strand | 20 | 1 | 12 |
| α-helix | 21-23 | 3 | |
| α-helix | 25-30 | 6 | |
| α-helix | 34-36 | 3 | |
| β-strand | 37-39 | 3 | 12 |
| α-helix | 42-44 | 3 | |
| α-helix | 45-51 | 7 | |
| β-strand | 55 | 1 | 10 |
| α-helix | 62-75 | 14 | |
| β-strand | 79 | 1 | 13 |
| α-helix | 82-84 | 3 | |
| α-helix | 85-90 | 6 | |
| α-helix | 96-99 | 4 | |
| α-helix | 105-109 | 5 | |
| α-helix | 113-128 | 16 | |
| α-helix | 133-135 | 3 | |
| β-strand | 136-140 | 5 | 11 |
| β-strand | 144-146 | 3 | 12 |
| β-strand | 148 | 1 | 14 |
| α-helix | 149-151 | 3 | |
| β-strand | 153 | 1 | 14 |
| α-helix | 155-158 | 4 | |
| β-strand | 159-162 | 4 | 11 |
| α-helix | 165-187 | 23 | |
| α-helix | 188-190 | 3 | |
| β-strand | 191 | 1 | 15 |
| α-helix | 192-194 | 3 | |
| α-helix | 197-209 | 13 | |
| β-strand | 214-219 | 6 | 15 |
| β-strand | 221 | 1 | 16 |
| α-helix | 224-227 | 4 | |
| α-helix | 230-240 | 11 | |
| β-strand | 244 | 1 | 13 |
| α-helix | 247-256 | 10 | |
| α-helix | 257-261 | 5 | |
| β-strand | 264-267 | 4 | 11 |
| β-strand | 273-277 | 5 | 11 |
| α-helix | 287-306 | 20 | |
| β-strand | 309-316 | 8 | 15 |
| β-strand | 319-325 | 7 | 15 |
| α-helix | 329-345 | 17 | |
| β-strand | 350 | 1 | 16 |
| β-strand | 357 | 1 | 15 |
| α-helix | 360-362 | 3 | |
| β-strand | 365 | 1 | 17 |
| β-strand | 368 | 1 | 17 |
| β-strand | 369-374 | 6 | 18 |
| β-strand | 380-385 | 6 | 18 |
| α-helix | 389-400 | 12 | |
| α-helix | 407-414 | 8 | |
| α-helix | 419-420 | 2 | |
| α-helix | 421-426 | 6 | |
| α-helix | 427-435 | 9 | |
| β-strand | 443-447 | 5 | 19 |
| β-strand | 450-454 | 5 | 19 |
| α-helix | 456-458 | 3 | |
| α-helix | 459-467 | 9 | |
| α-helix | 469-472 | 4 | |
| β-strand | 475 | 1 | 18 |
| α-helix | 479-492 | 14 | |
| α-helix | 494-496 | 3 | |
| α-helix | 497-512 | 16 | |
| α-helix | 516-520 | 5 | |
| α-helix | 521-525 | 5 | |
| α-helix | 527-529 | 3 | |
| α-helix | 533-535 | 3 | |
| α-helix | 537-539 | 3 | |
| α-helix | 540-544 | 5 | |
| β-strand | 561 | 1 | 19 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| RNA-directed RNA polymerase | A, B | protein | 576 | Hepatitis C virus (isolate H77) | P27958 (AlphaFold model) |
>2XI3_1 RNA-directed RNA polymerase (chains A, B) SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYSTTSRSACQRQKKVTFDRLQVL DSHYHDVLKEVKAAASKVKANLLSVEEACSLTPPHSAKSKFGYGAKDVRCHARKAVAHIN SVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS KLPLAVMGSSYGFQYSPGQRVEFLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIY QCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCRASGVLTTSCGNTLTCYIKAR AACRAAGLQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLW ARMILMTHFFSVLIARDQLEQALNCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPG EINRVAACLRKLGVPPLRAWRHRARSVRARLLSRGGRAAICGKYLFNWAVRTKLKLTPIA AAGRLDLSGWFTAGYSGGDIYHSVSHARPRHHHHHH
Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis. Harrus, D., Ahmed-El-Sayed, N., Simister, P.C. et al. J Biol Chem (2010) 285:32906. DOI 10.1074/JBC.M110.151316 · PubMed
Other PDB entries of the same protein (UniProt P27958 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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