Structure of the hepatitis C virus envelope glycoprotein E2 antigenic 2 region 412-423 bound to the broadly neutralizing antibody HC33.1. Determined by X-ray diffraction at 2.0 Å resolution. Released 11 Mar 2015.
Explore 4XVJ in 3D Show helices and sheets RCSB PDB PDBe
4XVJ contains 3 α-helices and 25 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 414-415 | 2 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-7 | 5 | 2 |
| β-strand | 11-12 | 2 | 3 |
| β-strand | 18-25 | 8 | 2 |
| β-strand | 33-39 | 7 | 1 |
| β-strand | 45-52 | 8 | 1 |
| β-strand | 58-60 | 3 | 1 |
| β-strand | 68-72 | 5 | 2 |
| β-strand | 78-83 | 6 | 2 |
| α-helix | 88-90 | 3 | |
| β-strand | 92-103 | 12 | 1 |
| β-strand | 110-117 | 8 | 1 |
| β-strand | 121-123 | 3 | 1 |
| β-strand | 124-125 | 2 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5 | 1 | 4 |
| β-strand | 9-12 | 4 | 5 |
| β-strand | 18-23 | 6 | 4 |
| α-helix | 26-30 | 5 | |
| β-strand | 35-39 | 5 | 5 |
| β-strand | 46-49 | 4 | 5 |
| β-strand | 50 | 1 | 6 |
| β-strand | 54 | 1 | 6 |
| β-strand | 63-68 | 6 | 4 |
| β-strand | 71-76 | 6 | 4 |
| α-helix | 81-83 | 3 | |
| β-strand | 85-93 | 9 | 5 |
| β-strand | 98-101 | 4 | 5 |
| β-strand | 105-109 | 5 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| HCV E2 antigen | A | protein | 13 | Hepatitis C virus | P27958 (AlphaFold model) |
| antibody heavy chain variable domain | H | protein | 141 | Homo sapiens | |
| antibody light chain variable domain | L | protein | 115 | Homo sapiens |
>4XVJ_1 HCV E2 antigen (chains A) RQLINTNGSWHIN
>4XVJ_2 antibody heavy chain variable domain (chains H) MEVQLVESGGGLVQPGGSLRLSCVASGLTFTNFAVSWVRQAPGKGLEWVSAISSSDGSTY YSDSVKGRFTISRDSSMNTLYLQMDSLRVEDTAVYFCARAVVSSDITYTYWSKYFDYWGQ GTLVTVSSGSTGGGGSGGGGS
>4XVJ_3 antibody light chain variable domain (chains L) GGGGSQSVVTQPPSVSAAPGQKVTISCSGGSFNIGNNYVSWYQQLPGTAPKLLIYDNDNR PSGIPDRFSGSKSGTSATLDITGLQTGDEADYYCGTWDSSLNVVVFGGGTKLTVL
Structural basis for penetration of the glycan shield of hepatitis C virus e2 glycoprotein by a broadly neutralizing human antibody. Li, Y., Pierce, B.G., Wang, Q. et al. J Biol Chem (2015) 290:10117-10125. DOI 10.1074/jbc.M115.643528 · PubMed
Other PDB entries of the same protein (UniProt P27958 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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