Solution structure of the chimera of the C-terminal PID domain of Fe65L and the C-terminal tail peptide of APP. Determined by solution NMR. Released 8 Apr 2008.
Explore 2YSZ in 3D Show helices and sheets RCSB PDB PDBe
2YSZ contains 4 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 16-28 | 13 | 1 |
| α-helix | 34-47 | 14 | |
| α-helix | 54 | 1 | |
| β-strand | 55-61 | 7 | 1 |
| β-strand | 64-69 | 6 | 1 |
| β-strand | 76-80 | 5 | 1 |
| β-strand | 87-89 | 3 | 1 |
| β-strand | 96-102 | 7 | 1 |
| β-strand | 108-115 | 8 | 1 |
| α-helix | 122-131 | 10 | |
| α-helix | 159-167 | 9 | |
| β-strand | 172-173 | 2 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Amyloid beta A4 precursor protein-binding family B member 2 and Amyloid beta A4 protein | A | protein | 185 | Mus musculus | Q9DBR4 (AlphaFold model) |
>2YSZ_1 Amyloid beta A4 precursor protein-binding family B member 2 and Amyloid beta A4 protein (chains A) GSSGSSGPTPKTELVQKFRVQYLGMLPVDRPVGMDTLNSAIENLMTSSSKEDWPSVNMNV ADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAA NVSEAVQAACSGPSSGIEGRGSSGSSGSSGSSGDAAVTPEERHLSKMQQNGYENPTYKFF EQMQN
Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode. Li, H., Koshiba, S., Hayashi, F. et al. J Biol Chem (2008) 283:27165-27178. DOI 10.1074/jbc.M803892200 · PubMed
Other PDB entries of the same protein (UniProt Q9DBR4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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