2Z7F: Leukocyte elastase

Crystal structure of the complex of human neutrophil elastase with 1/2SLPI. Determined by X-ray diffraction at 1.7 Å resolution. Released 26 Aug 2008.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,307
Mol. weight: 29.58 kDa
Released: 26 Aug 2008

Explore 2Z7F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2Z7F contains 11 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain E: 9 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	17	1	1
β-strand	20-21	2	2
α-helix	22-23	2
β-strand	30-35	6	3
β-strand	39-48	10	3
β-strand	51-54	4	3
α-helix	56-59	4
α-helix	62B-64	3
β-strand	65A-68	4	3
β-strand	72	1	4
β-strand	81-90	10	3
β-strand	95	1	5
β-strand	100	1	5
β-strand	104-108	5	3
α-helix	112-114	3
α-helix	124-125	2
α-helix	130-131	2
β-strand	135-140	6	2
β-strand	143	1	6
β-strand	151	1	6
β-strand	154	1	4
β-strand	156-164	8	2
β-strand	181-184	4	2
β-strand	189	1	1
β-strand	198-201	4	2
β-strand	208-216	9	2
α-helix	225	1
β-strand	226-230	5	2
α-helix	231-234	4
α-helix	235-242	8

Chain I: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	63	1	7
α-helix	64-66	3
β-strand	70-71	2	2
α-helix	83-85	3
β-strand	91-95	5	8
β-strand	98-102	5	8
β-strand	105	1	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Leukocyte elastase	E	protein	218	Homo sapiens	P08246 (AlphaFold model)
Antileukoproteinase	I	protein	50	Homo sapiens	P03973 (AlphaFold model)

Sequence of entity 1 (E), FASTA

>2Z7F_1 Leukocyte elastase (chains E)
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNL
SRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGV
QCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCN
GLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQ

Sequence of entity 2 (I), FASTA

>2Z7F_2 Antileukoproteinase (chains I)
RRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA

Primary citation

Complex of human neutrophil elastase with 1/2SLPI. Koizumi, M., Fujino, A., Fukushima, K. et al. J Synchrotron Radiat (2008) 15:308-311. DOI 10.1107/S0909049507060670 · PubMed

Other PDB entries of the same protein (UniProt P08246 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SI4 1.14 Å, Structure of human neutrophil elastase in complex with a…
8VK5 1.56 Å, Human Sputum Leucocyte Elastase (uncomplexed)
5ABW 1.6 Å, Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases
4WVP 1.63 Å, Crystal structure of an activity-based probe HNE complex
9ASS 1.75 Å, Crystal Structure of Neutrophil Elastase Inhibited by Eap4 from S. aureus
5A0A 1.78 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
1PPF 1.8 Å, X-ray crystal structure of the complex of human leukocyte elastase (pmn elastase) and…
2RG3 1.8 Å, Covalent complex structure of elastase
8G25 1.8 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
5A09 1.81 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
8G24 1.82 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
1HNE 1.84 Å, Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone…

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