8VK5: Human Sputum Leucocyte Elastase

Human Sputum Leucocyte Elastase (uncomplexed). Determined by X-ray diffraction at 1.56 Å resolution. Released 15 Jan 2025.

Method: X-ray diffraction
Resolution: 1.56 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,054
Mol. weight: 24.26 kDa
Released: 15 Jan 2025

Explore 8VK5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8VK5 contains 6 α-helices and 23 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain E: 6 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	1
β-strand	5-6	2	2
α-helix	7-8	2
β-strand	15-20	6	3
β-strand	23-32	10	3
β-strand	35-38	4	3
α-helix	40-43	4
α-helix	48-50	3
β-strand	52-55	4	3
β-strand	59	1	4
β-strand	68-77	10	3
β-strand	81	1	5
β-strand	86	1	5
β-strand	90-94	5	3
β-strand	101	1	6
β-strand	104	1	6
β-strand	121-126	6	2
β-strand	129	1	7
β-strand	136	1	7
β-strand	139	1	4
β-strand	141-148	8	2
β-strand	157-160	4	2
β-strand	167	1	1
β-strand	176-179	4	2
β-strand	182-189	8	2
α-helix	200	1
β-strand	201-205	5	2
α-helix	206-209	4
α-helix	210-217	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neutrophil elastase	E	protein	218	Homo sapiens	P08246 (AlphaFold model)

Sequence of entity 1 (E), FASTA

>8VK5_1 Neutrophil elastase (chains E)
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNL
SRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGV
QCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCN
GLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQ

Primary citation

Human Sputum Leucocyte Elastase (uncomplexed). Rajasekaran, G., Xu, J., Li, S. et al. To be published.

Other PDB entries of the same protein (UniProt P08246 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SI4 1.14 Å, Structure of human neutrophil elastase in complex with a…
5ABW 1.6 Å, Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases
4WVP 1.63 Å, Crystal structure of an activity-based probe HNE complex
2Z7F 1.7 Å, Crystal structure of the complex of human neutrophil elastase with 1/2SLPI
9ASS 1.75 Å, Crystal Structure of Neutrophil Elastase Inhibited by Eap4 from S. aureus
5A0A 1.78 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
1PPF 1.8 Å, X-ray crystal structure of the complex of human leukocyte elastase (pmn elastase) and…
2RG3 1.8 Å, Covalent complex structure of elastase
8G25 1.8 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
5A09 1.81 Å, Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone…
8G24 1.82 Å, Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at…
1HNE 1.84 Å, Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone…

Browse structure collections

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