Neutrophil elastase (ELANE) is a 267-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08246.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 88.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes (PubMed:15140022). Shows microbicidal activity in neutrophils by mediating cleavage and degradation of bacterial proteins (PubMed:10947984, PubMed:25161283). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Involved for the formation of neutrophil extracellular traps (NETs): translocates into the nucleus downstream of MPO and mediates degadation of histone H4, thereby participating to chromatin decondensation (PubMed:20974816, PubMed:25066128, PubMed:28574339). NETs are mainly composed of DNA fibers and are…
Interacts with NOTCH2NL (PubMed:14673143). Interacts with agaphelin, an antihemostatic protein from Anopheles gambiae (PubMed:25211214)
Cytoplasmic vesicle, phagosome, Lysosome, Cytolytic granule, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9SI4 | X-ray | 1.14 Å | A=30-247 |
| 8VK5 | X-ray | 1.56 Å | E=30-247 |
| 5ABW | X-ray | 1.6 Å | A=30-247 |
| 4WVP | X-ray | 1.63 Å | E=30-247 |
| 2Z7F | X-ray | 1.7 Å | E=30-247 |
| 9ASS | X-ray | 1.75 Å | A=30-247 |
| 5A0A | X-ray | 1.78 Å | E=30-247 |
| 1PPF | X-ray | 1.8 Å | E=30-247 |
| 2RG3 | X-ray | 1.8 Å | A=30-247 |
| 8G25 | X-ray | 1.8 Å | B/E/H=30-247 |
| 5A09 | X-ray | 1.81 Å | A=30-247 |
| 8G24 | X-ray | 1.82 Å | B=30-247 |
| 1HNE | X-ray | 1.84 Å | E=30-247 |
| 4NZL | X-ray | 1.85 Å | A=30-247 |
| 8G26 | X-ray | 1.85 Å | B=30-247 |
| 3Q76 | X-ray | 1.86 Å | A/B=30-247 |
| 5A8Y | X-ray | 1.9 Å | A=30-247 |
| 8D4U | X-ray | 1.9 Å | A/B=30-247 |
| 9ASX | X-ray | 1.96 Å | B=30-247 |
| 1H1B | X-ray | 2.0 Å | A/B=30-247 |
Showing 20 of 38 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.