2ZU1: CVB3 3C protease mutant C147A

crystal structure of CVB3 3C protease mutant C147A. Determined by X-ray diffraction at 1.38 Å resolution. Released 13 Jan 2009.

Method: X-ray diffraction
Resolution: 1.38 Å
Organism: Human coxsackievirus B3
Chains: 2
Atoms: 3,418
Mol. weight: 40.53 kDa
Released: 13 Jan 2009

Explore 2ZU1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ZU1 contains 13 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	2-14	13
β-strand	15-20	6	1
β-strand	23-31	9	1
β-strand	32	1	2
β-strand	34-38	5	1
α-helix	39-41	3
β-strand	46-49	4	1
β-strand	52-63	12	1
β-strand	69-77	9	1
α-helix	82	1
β-strand	83	1	2
α-helix	84	1
α-helix	87-89	3
β-strand	90	1	1
β-strand	97-104	8	1
β-strand	112-127	16	1
β-strand	130-139	10	1
α-helix	149	1
β-strand	150-153	4	1
β-strand	156-165	10	1
β-strand	168-173	6	1
α-helix	176-179	4

Chain B: 6 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	2-14	13
β-strand	15-20	6	1
β-strand	23-31	9	1
β-strand	32	1	3
β-strand	34-38	5	1
α-helix	39-41	3
β-strand	46-49	4	1
β-strand	52-63	12	1
β-strand	69-77	9	1
α-helix	82	1
β-strand	83	1	3
α-helix	84	1
α-helix	87-89	3
β-strand	90	1	1
β-strand	97-104	8	1
β-strand	112-127	16	1
β-strand	130-139	10	1
β-strand	150-153	4	1
β-strand	156-165	10	1
β-strand	168-173	6	1
α-helix	176-179	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
3C proteinase	A, B	protein	183	Human coxsackievirus B3	P03313

Sequence of entity 1 (A, B), FASTA

>2ZU1_1 3C proteinase (chains A, B)
GPAFEFAVAMMKRNSSTVKTEYGEFTMLGIYDRWAVLPRHAKPGPTILMNDQEVGVLDAK
ELVDKDGTNLELTLLKLNRNEKFRDIRGFLAKEEVEVNEAVLAINTSKFPNMYIPVGQVT
EYGFLNLGGTPTKRMLMYNFPTRAGQAGGVLMSTGKVLGIHVGGNGHQGFSAALLKHYFN
DEQ

Primary citation

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds. Lee, C.C., Kuo, C.J., Ko, T.P. et al. J Biol Chem (2009) 284:7646-7655. DOI 10.1074/jbc.M807947200 · PubMed

Other PDB entries of the same protein (UniProt P03313), best resolution first:

7W0Q 1.1 Å, TRIM7 in complex with C-terminal peptide of 2C
7W0S 1.4 Å, TRIM7 in complex with C-terminal peptide of 2C
6S3A 1.52 Å, Coxsackie B3 2C protein in complex with S-Fluoxetine
7W0T 1.57 Å, TRIM7 in complex with C-terminal peptide of 2C
7QUW 1.65 Å, CVB3-3Cpro in complex with inhibitor MG-78
2ZTX 1.72 Å, Complex structure of CVB3 3C protease with EPDTC
2ZTY 1.72 Å, crystal structure of 3C protease from CVB3 in space group C2
2ZU3 1.75 Å, Complex structure of CVB3 3C protease with TG-0204998
4WFZ 1.8 Å, Coxsackievirus B3 3Dpol RNA Dependent RNA Polymerase - NaCl Crystal Form
4WFX 1.81 Å, Coxsackievirus B3 Polymerase - F232L Mutant - NaCl Crystal Form
6T3W 1.82 Å, Coxsackie B3 2C protein in complex with S-Fluoxetine
8S6F 1.93 Å, A Structural Investigation of the Interaction between a GC-376-Based Peptidomimetic…

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