32QO: Human TRIM21 PRYSPRY domain

Human TRIM21 PRYSPRY domain in complex with compound 28 (Z38). Determined by X-ray diffraction at 1.3 Å resolution. Released 29 Jul 2026.

Method: X-ray diffraction
Resolution: 1.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,796
Mol. weight: 21.14 kDa
Ligands: A1KEG
Released: 29 Jul 2026

Explore 32QO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

32QO contains 3 α-helices and 17 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	287	1	1
β-strand	292	1	2
α-helix	294-296	3
β-strand	301-303	3	1
β-strand	309-312	4	1
β-strand	332-333	2	3
β-strand	334	1	2
β-strand	338	1	3
β-strand	342-348	7	1
β-strand	355-361	7	3
β-strand	378-384	7	3
β-strand	388-391	4	3
β-strand	397-398	2	3
β-strand	407-413	7	1
β-strand	418-423	6	1
α-helix	424-426	3
β-strand	429-434	6	1
β-strand	443-448	6	3
α-helix	459-460	2
β-strand	461-463	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase TRIM21	A	protein	181	Homo sapiens	P19474 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>32QO_1 E3 ubiquitin-protein ligase TRIM21 (chains A)
SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYW
EVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
L

Ligands and cofactors

ID	Name	Formula	Copies
A1KEG	~{N}-[[(1~{S},2~{R})-2-azanylcyclohexyl]methyl]-4-(4-fluoranyl-2-methylsulfanyl…	C23 H29 F N2 O3 S2	1

Water and common crystallization additives (EDO) are not listed.

Primary citation

Human TRIM21 PRYSPRY domain in complex with compound 28 (Z38). Kim, Y., Schallmayer, L., Knapp, S. et al. To be published.

Other PDB entries of the same protein (UniProt P19474 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9PLM 1.32 Å, TRIM21-NUP98 Molecular Glue Complex (MAN-021)
32QL 1.4 Å, Human TRIM21 PRYSPRY domain in complex with HGC652
9QBA 1.45 Å, Human TRIM21 PRYSPRY domain in complex with AL236
9II5 1.49 Å, Crystal structure of human TRIM21 PRYSPRY in complex with compound 1
32QM 1.5 Å, Human TRIM21 PRYSPRY domain in complex with compound 5 (Z31)
8Y58 1.6 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine.
9PLL 1.6 Å, TRIM21-NUP98 Molecular Glue Complex (MAN-056)
8Y5B 1.74 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (R)-hydroxyl-acepromazine.
32QN 1.8 Å, Human TRIM21 PRYSPRY domain in complex with compound 29 (Z37)
8Y59 1.89 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (S)-hydroxyl-acepromazine.
5OLM 1.95 Å, TRIM21
9M3N 2.08 Å, Crystal structure of human TRIM21 PRYSPRY in complex with T-02

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