3B21: OspI from Shigella flexineri

Crystal structure of OspI from Shigella flexineri. Determined by X-ray diffraction at 2.01 Å resolution. Released 22 Feb 2012.

Method: X-ray diffraction
Resolution: 2.01 Å
Organism: Shigella flexneri
Chains: 1
Atoms: 1,624
Mol. weight: 24.15 kDa
Released: 22 Feb 2012

Explore 3B21 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3B21 contains 13 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	24-32	9
α-helix	38-53	16
α-helix	63-73	11
β-strand	79	1	1
α-helix	80-83	4
α-helix	84-89	6
α-helix	91-93	3
α-helix	99-102	4
β-strand	107-108	2	2
α-helix	109-110	2
β-strand	114	1	3
α-helix	115-129	15
β-strand	135-140	6	2
β-strand	145-151	7	2
β-strand	156-159	4	2
β-strand	160	1	4
β-strand	165	1	4
β-strand	180	1	3
α-helix	181-182	2
β-strand	186-190	5	2
α-helix	194-201	8
α-helix	204-208	5
α-helix	210	1
β-strand	211	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ORF169b	A	protein	220	Shigella flexneri	Q8VSD5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3B21_1 ORF169b (chains A)
GPLGSPEFMINGVSLQGTAGYEAHTEEGNVNVKKLLESLNSKSLGDMDKDSELAATLQKM
INPSGGDGNCSGCALHACMAMLGYGVREAPVPNEISEYMTGFFHRHLEQIDSEGIVSHPN
ETYSKFRERIAENILQNTSKGSVVMISIEQATHWIAGFNDGEKIMFLDVQTGKGFNLYDP
VEKSPDAFVDENSSVQVIHVSDQEFDHYANSSSWKSKRLC

Primary citation

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Sanada, T., Kim, M., Mimuro, H. et al. Nature (2012) 483:623-626. DOI 10.1038/nature10894 · PubMed

Other PDB entries of the same protein (UniProt Q8VSD5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4XZX 2.2 Å, Shigella flexneri effector OspI C62S mutant
4IP3 2.3 Å, Complex structure of OspI and Ubc13
3W31 2.96 Å, Structual basis for the recognition of Ubc13 by the Shigella flexneri effector OspI
3W30 2.99 Å, Structual basis for the recognition of Ubc13 by the Shigella flexneri effector OspI

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