3BXL: Calmodulin

Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 25 Mar 2008.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Rattus norvegicus
Chains: 2
Atoms: 1,443
Mol. weight: 19.7 kDa
Ligands: CA
Released: 25 Mar 2008

Explore 3BXL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3BXL contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-77	13
α-helix	82-92	11
β-strand	100	1	2
α-helix	102-112	11
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-146	9

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1820-1834	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Rattus norvegicus	P0DP29 (AlphaFold model)
Voltage-dependent R-type calcium channel subunit alpha-1E peptide	B	protein	21		Q15878 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3BXL_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>3BXL_2 Voltage-dependent R-type calcium channel subunit alpha-1E peptide (chains B)
KIYAAMMIMDYYKQSKVKKQR

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Water and common crystallization additives (SO4) are not listed.

Primary citation

Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin. Mori, M.X., Vander Kooi, C.W., Leahy, D.J. et al. To be published.

Other PDB entries of the same protein (UniProt P0DP29 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2PQ3 1.3 Å, N-Terminal Calmodulin Zn-Trapped Intermediate
4J9Y 1.51 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
1G4Y 1.6 Å, 1.60 a crystal structure of the gating domain from small conductance potassium channel…
3B32 1.6 Å, Crystal Structure of Calcium-Saturated Calmodulin N-Terminal Domain Fragment, Residues…
4G28 1.63 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
4G27 1.65 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
4J9Z 1.66 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
9M6G 1.7 Å, the crystal structure of the Ca2+/CaM-CASK-CaMK-Mint1-CID complex
9KYS 1.76 Å, the Ca2+/CaM-CASK-ARD complex
6MBA 1.8 Å, Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin
9M5Y 1.8 Å, the crystal structure of the Ca2+/CaM-CASK-CaMK complex
9U9D 1.8 Å, Bipartite Genetically Encoded Biosensor sG-GECO1

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