3D8E: Human Fe65-PTB1 domain

Crystal structure of the human Fe65-PTB1 domain (trigonal crystal form). Determined by X-ray diffraction at 2.8 Å resolution. Released 10 Jun 2008.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,835
Mol. weight: 67.13 kDa
Released: 10 Jun 2008

Explore 3D8E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3D8E contains 15 α-helices and 30 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	369-380	12	1
α-helix	382-385	4
α-helix	390-401	12
β-strand	421-427	7	1
β-strand	430-435	6	1
β-strand	440-446	7	1
α-helix	447-449	3
β-strand	450-455	6	1
β-strand	464-470	7	1
β-strand	477-484	8	1
α-helix	489-503	15

Chain B: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	368-380	13	1
α-helix	382-385	4
α-helix	389-399	11
β-strand	421-427	7	1
β-strand	430-434	5	1
β-strand	441-443	3	1
β-strand	446	1	1
α-helix	447-449	3
β-strand	450-455	6	1
β-strand	464-470	7	1
β-strand	477-484	8	1
α-helix	488-504	17

Chain C: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	369-379	11	2
α-helix	390-401	12
β-strand	422-427	6	2
β-strand	430-434	5	2
β-strand	441-446	6	2
α-helix	447-449	3
β-strand	450-455	6	2
β-strand	464-470	7	2
β-strand	477-484	8	2
α-helix	488-504	17

Chain D: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	368-379	12	2
α-helix	383-385	3
α-helix	389-400	12
β-strand	421-427	7	2
β-strand	430-434	5	2
β-strand	441-443	3	2
β-strand	446	1	2
α-helix	447-449	3
β-strand	450-455	6	2
β-strand	464-470	7	2
β-strand	477-484	8	2
α-helix	488-504	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Amyloid beta A4 precursor protein-binding family B member 1	A, B, C, D	protein	148	Homo sapiens	O00213 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3D8E_1 Amyloid beta A4 precursor protein-binding family B member 1 (chains A, B, C, D)
GIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQ
LEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCE
APAKNIATSLHEICSKIMAELEHHHHHH

Primary citation

Crystal structure of the human Fe65-PTB1 domain. Radzimanowski, J., Ravaud, S., Schlesinger, S. et al. J Biol Chem (2008) 283:23113-23120. DOI 10.1074/jbc.M800861200 · PubMed

Other PDB entries of the same protein (UniProt O00213 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2HO2 1.33 Å, Structure of human FE65-WW domain in complex with hMena peptide.
2OEI 1.35 Å, Crystal structure of human FE65-WW domain in complex with human Mena peptide
3DXE 2.0 Å, Crystal structure of the intracellular domain of human APP (T668A mutant) in complex…
3DXC 2.1 Å, Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2
3D8D 2.2 Å, Crystal structure of the human Fe65-PTB1 domain
3DXD 2.2 Å, Crystal structure of the intracellular domain of human APP (T668E mutant) in complex…
2IDH 2.28 Å, Crystal Structure of human FE65 WW domain
5NQH 2.6 Å, Structure of the human Fe65-PTB2 homodimer
3D8F 2.7 Å, Crystal structure of the human Fe65-PTB1 domain with bound phosphate (trigonal crystal…
2E45 Solution structure of Fe65 WW domain

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