3F1N: Endothelial PAS domain-containing protein 1

Name: PDB 3F1N: Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
Published: 2009-01-20
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol. Determined by X-ray diffraction at 1.48 Å resolution. Released 20 Jan 2009.

Method: X-ray diffraction
Resolution: 1.48 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,120
Mol. weight: 27.97 kDa
Released: 20 Jan 2009

Explore 3F1N in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3F1N contains 13 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	240-242	3
β-strand	243-248	6	1
β-strand	253	1	2
β-strand	254-257	4	1
α-helix	260-265	6
α-helix	269-272	4
β-strand	273	1	1
β-strand	276	1	2
α-helix	277-280	4
β-strand	281	1	1
α-helix	283-285	3
α-helix	286-299	14
β-strand	301-303	3	1
α-helix	304-305	2
β-strand	307-310	4	1
β-strand	316-326	11	1
β-strand	336-343	8	1
β-strand	348	1	1

Chain B: 6 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	358-361	4
β-strand	362-367	6	3
β-strand	372	1	4
β-strand	373-376	4	3
α-helix	380-384	5
α-helix	388-391	4
β-strand	395	1	4
α-helix	396-399	4
β-strand	400	1	3
α-helix	405-415	11
β-strand	423-430	8	3
β-strand	436-446	11	3
α-helix	453-455	3
β-strand	456-463	8	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Endothelial PAS domain-containing protein 1	A	protein	117	Homo sapiens	Q99814 (AlphaFold model)
Aryl hydrocarbon receptor nuclear translocator	B	protein	121	Homo sapiens	P27540 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3F1N_1 Endothelial PAS domain-containing protein 1 (chains A)
GEFKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSH
QNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKN

Sequence of entity 2 (B), FASTA

>3F1N_2 Aryl hydrocarbon receptor nuclear translocator (chains B)
GEFKGLNVCQPTRFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLR
DSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQ
E

Primary citation

Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Scheuermann, T.H., Tomchick, D.R., Machius, M. et al. Proc Natl Acad Sci U S A (2009) 106:450-455. DOI 10.1073/pnas.0808092106 · PubMed

Other PDB entries of the same protein (UniProt Q99814 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3F1P 1.17 Å, Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS…
7Q5V 1.17 Å, Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with N-oxalylglycine (NOG) and hif-2…
7Q5X 1.21 Å, Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 2-oxoglutarate (2OG) and hif-2…
8Q64 1.36 Å, Crystal structure of hydroxylated HIF2alpha-CODD peptide (523-542) bound to apo-HIF…
8Q6E 1.37 Å, Aerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with…
8RV1 1.39 Å, HIF prolyl hydroxylase 2 (PHD2) T387S variant bound to acetate (ACT) and hydroxylated…
8Q6D 1.4 Å, Anaerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with…
8Q5S 1.49 Å, Anaerobic crystal structure of apo-HIF prolyl hydroxylase 2 (PHD2 181-407)in complex…
3H82 1.5 Å, Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS…
4GHI 1.5 Å, Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS…
6D0C 1.5 Å, Crystal structure of HIF2a-B*:ARNT-B* complex
6X21 1.54 Å, Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex

Browse structure collections

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