3GQC: Human Rev1-DNA-dNTP ternary complex

Structure of human Rev1-DNA-dNTP ternary complex. Determined by X-ray diffraction at 2.5 Å resolution. Released 19 May 2009.

Method

X-ray diffraction

Resolution

2.5 Å

Organism

Homo sapiens

Chains

12

Atoms

15,522

Mol. weight

260.17 kDa

Ligands

DCP, MG

Released

19 May 2009

Explore 3GQC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3GQC contains 102 α-helices and 74 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 28 helices, 20 β-strands

Molecules and chains

>3GQC_1 DNA repair protein REV1 (chains A, B, C, D)
STFSKAAPSVPSKPSDCNFISNFYSHSRLHHISMWKCELTEFVNTLQRQSNGIFPGREKL
KKMKTGRSALVVTDTGDMSVLNSPRHQSCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSN
RGTGRAPLRPGANPQLEWQYYQNKILKGKAADIPDSSLWENPDSAQANGIDSVLSRAEIA
SCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDFHAYKEVAQTLYETLASYTHNIEAVSC
DEALVDITEILAETKLTPDEFANAVRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQ
YHLKPEEVDDFIRGQLVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTGQ
MLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEATGMK
GKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNAKIIGKAMLNMFHTMKL
NISDMRGVGIHVNQLVPTNLNPST

>3GQC_2 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*(DOC))-3' (chains E, G, I, K)
ATCCTCCCCTAC

>3GQC_3 5'-D(*TP*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3' (chains F, H, J, L)
TAAGGTAGGGGAGGAT

Ligands and cofactors

Primary citation

Structure of the human Rev1-DNA-dNTP ternary complex. Swan, M.K., Johnson, R.E., Prakash, L. et al. J Mol Biol (2009) 390:699-709. DOI 10.1016/j.jmb.2009.05.026 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9UBZ9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4EXT 1.9 Å, Structure of polymerase-interacting domain of human Rev1 in complex with translesional…
• 6WS0 2.24 Å, Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT
• 6ASR 2.36 Å, REV1 UBM2 domain complex with ubiquitin
• 6WS5 2.47 Å, Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT
• 4GK0 2.7 Å, Crystal structure of human Rev3-Rev7-Rev1 complex
• 9VGW 2.7 Å, Crystal structure of human PCNA in complex with REV1 PIP-box
• 4BA9 2.73 Å, The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1
• 3VU7 2.8 Å, Crystal structure of REV1-REV7-REV3 ternary complex
• 4GK5 3.21 Å, Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex
• 2EBW Solution structure of the BRCT domain from human DNA repair protein REV1
• 2LSI Solution structure of polymerase-interacting domain of human Rev1 in complex with…
• 2LSK C-terminal domain of human REV1 in complex with DNA-polymerase H (eta)

Browse structure collections

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