3HFE: A trimeric form of the Kv7.1 A domain Tail

A trimeric form of the Kv7.1 A domain Tail. Determined by X-ray diffraction at 1.7 Å resolution. Released 1 Sept 2009.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 3
Atoms: 701
Mol. weight: 10.16 kDa
Released: 1 Sept 2009

Explore 3HFE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3HFE contains 3 α-helices and 0 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	588-609	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Potassium voltage-gated channel subfamily KQT member 1	A, B, C	protein	31	Homo sapiens	P51787 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>3HFE_1 Potassium voltage-gated channel subfamily KQT member 1 (chains A, B, C)
GARGSNTIGARLNRVEDKVTQLDQRLALITD

Primary citation

Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Xu, Q., Minor, D.L. Protein Sci (2009) 18:2100-2114. DOI 10.1002/pro.224 · PubMed

Other PDB entries of the same protein (UniProt P51787 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3BJ4 2.0 Å, The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein…
7VVH 2.3 Å, Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease…
3HFC 2.45 Å, A trimeric form of the Kv7.1 A domain Tail, L602M/L606M mutant Semet
7XNN 2.5 Å, human KCNQ1-CaM-ML277-PIP2 complex in state B
9UJ4 2.59 Å, Structure of human KCNQ1-CaM complex
7XNK 2.6 Å, human KCNQ1-CaM in complex with ML277
7VUO 2.68 Å, Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease…
9VEC 2.7 Å, structure of human KCNQ1-KCNE1-CaM complex
4V0C 2.86 Å, Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin
8SIK 2.9 Å, KCNQ1 with voltage sensor in the up conformation
9U7F 2.9 Å, structure of human KCNQ1-KCNE1-CaM complex
4UMO 3.0 Å, Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin

Browse structure collections

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