3I5Q: Nup170(aa1253-1502)

Nup170(aa1253-1502) at 2.2 A, S.cerevisiae. Determined by X-ray diffraction at 2.2 Å resolution. Released 11 Aug 2009.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Saccharomyces cerevisiae
Chains: 2
Atoms: 4,432
Mol. weight: 58.56 kDa
Released: 11 Aug 2009

Explore 3I5Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3I5Q contains 32 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 0 β-strands

Element	Residues	Length
α-helix	1262-1264	3
α-helix	1265-1281	17
α-helix	1287-1299	13
α-helix	1304-1307	4
α-helix	1308-1312	5
α-helix	1318-1327	10
α-helix	1333-1349	17
α-helix	1357-1378	22
α-helix	1387-1401	15
α-helix	1404-1406	3
α-helix	1413-1419	7
α-helix	1423-1436	14
α-helix	1442-1458	17
α-helix	1460-1463	4
α-helix	1468-1472	5
α-helix	1483-1491	9

Chain B: 16 helices, 0 β-strands

Element	Residues	Length
α-helix	1262-1264	3
α-helix	1265-1281	17
α-helix	1287-1299	13
α-helix	1304-1306	3
α-helix	1307-1312	6
α-helix	1318-1327	10
α-helix	1333-1350	18
α-helix	1357-1378	22
α-helix	1387-1401	15
α-helix	1404-1406	3
α-helix	1413-1419	7
α-helix	1423-1435	13
α-helix	1442-1458	17
α-helix	1460-1463	4
α-helix	1469-1472	4
α-helix	1483-1491	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nucleoporin NUP170	A, B	protein	252	Saccharomyces cerevisiae	P38181 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3I5Q_1 Nucleoporin NUP170 (chains A, B)
GPQRIVQLASRIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFND
FAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNV
LIKIGKNVQDSEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYIL
KELIETSDSDNSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKN
SGNNLGICFYKE

Primary citation

Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. Whittle, J.R., Schwartz, T.U. J Biol Chem (2009) 284:28442-28452. DOI 10.1074/jbc.M109.023580 · PubMed

Other PDB entries of the same protein (UniProt P38181 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3I5P 3.2 Å, Nup170(aa979-1502), S.cerevisiae
7WOO 3.71 Å, Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear…
7WOT 3.73 Å, Cryo-EM structure of the inner ring monomer of the Saccharomyces cerevisiae nuclear pore…
8TJ5 6.6 Å, Inner spoke ring of the yeast NPC
7N85 7.6 Å, Inner ring spoke from the isolated yeast NPC
7N9F 37.0 Å, Structure of the in situ yeast NPC
8ZZA Integrative structure and functional anatomy of a single spoke of a nuclear pore complex
8ZZB Integrative structure and functional anatomy of three spokes of a nuclear pore complex
8ZZC Integrative structure and functional anatomy of eight spokes of a nuclear pore complex
9A0F Integrative model of the wild type yeast nuclear pore complex
9A0G Integrative model of Nup116 knockout (at 25C) yeast nuclear pore complex
9A1P Comprehensive structure and functional adaptations of the yeast nuclear pore complex

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