3KUP: CBX3 Chromo Shadow Domain

Crystal Structure of the CBX3 Chromo Shadow Domain. Determined by X-ray diffraction at 1.77 Å resolution. Released 8 Dec 2009.

Method: X-ray diffraction
Resolution: 1.77 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,959
Mol. weight: 28.91 kDa
Released: 8 Dec 2009

Explore 3KUP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3KUP contains 16 α-helices and 12 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and D: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	116-119	4
α-helix	121-122	2
β-strand	123-130	8	1
β-strand	137-142	6	1
β-strand	149-152	4	1
α-helix	153-159	7
α-helix	161-171	11

Chain B: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	116-119	4
α-helix	121-122	2
β-strand	123-130	8	2
β-strand	137-142	6	2
β-strand	148-152	5	2
α-helix	153-159	7
α-helix	161-172	12

Chain C: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	116-119	4
α-helix	121-122	2
β-strand	123-130	8	3
β-strand	137-142	6	3
β-strand	148-152	5	3
α-helix	153-159	7
α-helix	161-171	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Chromobox protein homolog 3	A, B, C, D	protein	65	Homo sapiens	Q13185 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3KUP_1 Chromobox protein homolog 3 (chains A, B, C, D)
GAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFY
EERLT

Primary citation

Crystal Structure of the CBX3 Chromo Shadow Domain. Tempel, W., Li, Z., Li, Y. et al. To be published.

Other PDB entries of the same protein (UniProt Q13185 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5T1I 1.6 Å, CBX3 chromo shadow domain in complex with histone H3 peptide
9OSC 1.77 Å, Crystal structure of HP1gamma chromoshadow domain in complex with KAP1 peptide
8JZW 1.8 Å, Cystal structure of HP1 in complex with TRIM66 peptide
3TZD 1.81 Å, Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3)
6HW2 1.94 Å, The Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domains
3DM1 2.4 Å, Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide
2L11 Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide

Browse structure collections

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