3LVH: Clathrin heavy chain 1

Crystal structure of a clathrin heavy chain and clathrin light chain complex. Determined by X-ray diffraction at 9.0 Å resolution. Released 9 Jun 2010.

Method

X-ray diffraction

Resolution

9.0 Å

Organism

Bos taurus

Chains

6

Atoms

16,020

Mol. weight

281.05 kDa

Released

9 Jun 2010

Explore 3LVH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3LVH contains 127 α-helices and 8 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and C: 37 helices, 2 β-strands

Molecules and chains

>3LVH_1 Clathrin heavy chain 1 (chains A, B, C)
MGSSHHHHHHSSGLVPRGSHMLKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQL
AKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVET
ELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTL
VHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQ
DRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRA
AEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFY
LEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLF
ITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKD
SLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNI
MDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPP
QAPFGYGYTAPAYGQPQPGFGYSM

>3LVH_2 Clathrin light chain B (chains D, E, F)
MADDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDEGFGAPAGSQGGLAQPGPA
SGASEDMGATVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQELDAAS
KVMEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX

Primary citation

Conformation switching of clathrin light chain regulates clathrin lattice assembly. Wilbur, J.D., Hwang, P.K., Ybe, J.A. et al. Dev Cell (2010) 18:841-848. DOI 10.1016/j.devcel.2010.04.007 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P49951 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 5M5T 1.7 Å, Clathrin heavy chain N-terminal domain bound to a non-natural clathrin-box motif peptide…
• 9F8T 1.71 Å, Clathrin terminal domain complexed with C-terminus of AAK1L
• 5M5R 1.76 Å, Clathrin heavy chain N-terminal domain bound to beta2 adaptin clathrin box motif
• 5M61 1.84 Å, Clathrin heavy chain N-terminal domain bound to an extended amphiphysin clathrin-box motif
• 5M5S 1.88 Å, Clathrin heavy chain N-terminal domain bound to amphiphysin clathrin-box motif
• 5M5V 1.96 Å, Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D…
• 5M5U 2.15 Å, Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D…
• 3GC3 2.2 Å, Crystal Structure of Arrestin2S and Clathrin
• 1UTC 2.3 Å, Clathrin terminal domain complexed with TLPWDLWTT
• 1B89 2.6 Å, Clathrin heavy chain proximal leg segment (BOVINE)
• 3GD1 3.5 Å, Structure of an Arrestin/Clathrin complex reveals a novel clathrin binding domain that…
• 3QIL 3.92 Å, Crystal structure analysis of the clathrin trimerization domain

Browse structure collections

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