3M03: Human Orc6 fragment

Crystal structure of human Orc6 fragment. Determined by X-ray diffraction at 2.5 Å resolution. Released 9 Mar 2011.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Homo sapiens
Chains: 3
Atoms: 2,176
Mol. weight: 31.75 kDa
Released: 9 Mar 2011

Explore 3M03 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3M03 contains 22 α-helices and 2 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	95-97	3
α-helix	98-105	8
α-helix	108-110	3
α-helix	111-122	12
α-helix	127-132	6
α-helix	138-151	14
α-helix	158-163	6
β-strand	167	1	1
α-helix	169-183	15

Chain B: 8 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	96-97	2
α-helix	98-105	8
α-helix	108-110	3
α-helix	111-124	14
α-helix	127-132	6
β-strand	133	1	1
α-helix	138-152	15
α-helix	158-165	8
α-helix	169-183	15

Chain C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	100-103	4
α-helix	108-110	3
α-helix	111-121	11
α-helix	138-151	14
α-helix	158-165	8
α-helix	169-180	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Origin recognition complex subunit 6	A, B, C	protein	95	Homo sapiens	Q9Y5N6 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>3M03_1 Origin recognition complex subunit 6 (chains A, B, C)
MSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKIL
KLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVD

Primary citation

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. Liu, S.X., Balasov, M., Wang, H.F. et al. Proc Natl Acad Sci U S A (2011) 108:7373-7378. DOI 10.1073/pnas.1013676108 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5N6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8S0B 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
8S0D 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC1-6
6KVG The solution structure of human Orc6

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