8S0B: H. sapiens MCM
H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex. Determined by electron microscopy at 3.6 Å resolution. Released 2 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 3.6 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 9
- Atoms
- 32,424
- Mol. weight
- 605.92 kDa
- Ligands
- AGS, ADP, ZN, MG
- Released
- 2 Oct 2024
Explore 8S0B in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8S0B contains 188 α-helices and 173 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 32 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 182-187 | 6 | |
| α-helix | 189-205 | 17 | |
| α-helix | 214-224 | 11 | |
| β-strand | 229-232 | 4 | 1 |
| α-helix | 234-240 | 7 | |
| α-helix | 243-247 | 5 | |
| α-helix | 248-250 | 3 | |
| α-helix | 252-270 | 19 | |
| α-helix | 274-277 | 4 | |
| β-strand | 282-285 | 4 | 1 |
| α-helix | 294-296 | 3 | |
| α-helix | 299-301 | 3 | |
| β-strand | 305-315 | 11 | 2 |
| β-strand | 319-323 | 5 | 2 |
| β-strand | 325 | 1 | 3 |
| β-strand | 327-328 | 2 | 4 |
| β-strand | 335 | 1 | 4 |
| α-helix | 336-338 | 3 | |
| β-strand | 339 | 1 | 3 |
| β-strand | 362-363 | 2 | 4 |
| β-strand | 369-379 | 11 | 2 |
| α-helix | 386 | 1 | |
| β-strand | 393-399 | 7 | 2 |
| α-helix | 400-402 | 3 | |
| β-strand | 411-419 | 9 | 2 |
| β-strand | 434 | 1 | 5 |
| β-strand | 438-445 | 8 | 2 |
| α-helix | 459-468 | 10 | |
| α-helix | 473-480 | 8 | |
| α-helix | 489-500 | 12 | |
| β-strand | 505 | 1 | 6 |
| β-strand | 513 | 1 | 6 |
| β-strand | 519-523 | 5 | 7 |
| α-helix | 530-539 | 10 | |
| β-strand | 543-547 | 5 | 7 |
| β-strand | 559-562 | 4 | 8 |
| β-strand | 569-572 | 4 | 8 |
| α-helix | 573-574 | 2 | |
| α-helix | 575-578 | 4 | |
| β-strand | 583-587 | 5 | 7 |
| α-helix | 589-591 | 3 | |
| α-helix | 594-605 | 12 | |
| β-strand | 608-613 | 6 | 9 |
| β-strand | 616-621 | 6 | 9 |
| β-strand | 625-630 | 6 | 7 |
| α-helix | 643-646 | 4 | |
| α-helix | 651-656 | 6 | |
| β-strand | 659-663 | 5 | 7 |
| α-helix | 669-685 | 17 | |
| α-helix | 714-716 | 3 | |
| α-helix | 717-729 | 13 | |
| β-strand | 734 | 1 | 10 |
| α-helix | 740-757 | 18 | |
| α-helix | 764-780 | 17 | |
| β-strand | 785 | 1 | 10 |
| α-helix | 788-805 | 18 | |
| α-helix | 808-817 | 10 | |
| α-helix | 819-822 | 4 | |
| α-helix | 828-850 | 23 | |
Chain 3: 32 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-23 | 13 | |
| α-helix | 26-28 | 3 | |
| α-helix | 32-41 | 10 | |
| β-strand | 46-50 | 5 | 11 |
| α-helix | 51-57 | 7 | |
| α-helix | 59-67 | 9 | |
| α-helix | 70-87 | 18 | |
| α-helix | 89-92 | 4 | |
| β-strand | 99-103 | 5 | 11 |
| β-strand | 110 | 1 | 12 |
| α-helix | 118-120 | 3 | |
| β-strand | 124-133 | 10 | 12 |
| β-strand | 138-148 | 11 | 12 |
| β-strand | 153-158 | 6 | 12 |
| β-strand | 177 | 1 | 13 |
| β-strand | 183 | 1 | 13 |
| β-strand | 185-186 | 2 | 12 |
| β-strand | 192-202 | 11 | 12 |
| α-helix | 209 | 1 | |
| β-strand | 216-222 | 7 | 12 |
| α-helix | 223-225 | 3 | |
| β-strand | 233-244 | 12 | 12 |
| β-strand | 251-252 | 2 | 14 |
| β-strand | 255-256 | 2 | 15 |
| β-strand | 257-267 | 11 | 12 |
| α-helix | 280-290 | 11 | |
| α-helix | 295-301 | 7 | |
| α-helix | 311-322 | 12 | |
| β-strand | 327-328 | 2 | 16 |
| β-strand | 334-335 | 2 | 16 |
| β-strand | 341-345 | 5 | 17 |
| α-helix | 352-361 | 10 | |
| β-strand | 365-368 | 4 | 17 |
| α-helix | 375-378 | 4 | |
| β-strand | 381-382 | 2 | 18 |
| β-strand | 393-394 | 2 | 18 |
| α-helix | 397-400 | 4 | |
| β-strand | 405-408 | 4 | 17 |
| α-helix | 411-413 | 3 | |
| α-helix | 416-428 | 13 | |
| β-strand | 430-435 | 6 | 19 |
| β-strand | 438-443 | 6 | 19 |
| β-strand | 447-452 | 6 | 17 |
| α-helix | 465-469 | 5 | |
| α-helix | 473-478 | 6 | |
| β-strand | 481-485 | 5 | 17 |
| α-helix | 491-506 | 16 | |
| α-helix | 513 | 1 | |
| β-strand | 516 | 1 | 20 |
| β-strand | 545 | 1 | 21 |
| α-helix | 546-548 | 3 | |
| α-helix | 556-558 | 3 | |
| α-helix | 562 | 1 | |
| β-strand | 563 | 1 | 21 |
| α-helix | 564 | 1 | |
| α-helix | 565-577 | 13 | |
| β-strand | 581 | 1 | 22 |
| α-helix | 584-599 | 16 | |
| α-helix | 600-603 | 4 | |
| α-helix | 607 | 1 | |
| β-strand | 608-609 | 2 | 23 |
| α-helix | 616-631 | 16 | |
| β-strand | 636 | 1 | 22 |
| α-helix | 639-653 | 15 | |
| β-strand | 654-655 | 2 | 23 |
Chain 4: 25 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 159-172 | 14 | |
| α-helix | 192-203 | 12 | |
| β-strand | 207-211 | 5 | 24 |
| α-helix | 212-218 | 7 | |
| α-helix | 221-228 | 8 | |
| α-helix | 230-248 | 19 | |
| β-strand | 259-263 | 5 | 24 |
| α-helix | 266 | 1 | |
| β-strand | 267 | 1 | 25 |
| α-helix | 268 | 1 | |
| α-helix | 271-273 | 3 | |
| α-helix | 276-278 | 3 | |
| β-strand | 282-292 | 11 | 25 |
| β-strand | 296-306 | 11 | 25 |
| β-strand | 312-316 | 5 | 25 |
| β-strand | 327 | 1 | 26 |
| β-strand | 334 | 1 | 26 |
| β-strand | 337-356 | 20 | 25 |
| β-strand | 369-375 | 7 | 25 |
| α-helix | 376-378 | 3 | |
| β-strand | 387-397 | 11 | 25 |
| β-strand | 400-402 | 3 | 27 |
| β-strand | 405-409 | 5 | 27 |
| β-strand | 411 | 1 | 28 |
| β-strand | 413-422 | 10 | 25 |
| α-helix | 432-435 | 4 | |
| α-helix | 443-454 | 12 | |
| α-helix | 458-465 | 8 | |
| α-helix | 474-485 | 12 | |
| β-strand | 506-510 | 5 | 29 |
| α-helix | 517-524 | 8 | |
| β-strand | 530-534 | 5 | 29 |
| α-helix | 535-537 | 3 | |
| β-strand | 538 | 1 | 30 |
| β-strand | 545-549 | 5 | 31 |
| β-strand | 556-560 | 5 | 31 |
| α-helix | 562-565 | 4 | |
| β-strand | 569-574 | 6 | 29 |
| α-helix | 581-593 | 13 | |
| β-strand | 595-600 | 6 | 32 |
| β-strand | 603-608 | 6 | 32 |
| β-strand | 611-617 | 7 | 29 |
| α-helix | 630-634 | 5 | |
| α-helix | 638-641 | 4 | |
| β-strand | 646-650 | 5 | 29 |
| α-helix | 656-669 | 14 | |
| α-helix | 684-697 | 14 | |
| β-strand | 701-702 | 2 | 33 |
| α-helix | 704-721 | 18 | |
| α-helix | 731-747 | 17 | |
| β-strand | 752-753 | 2 | 33 |
| α-helix | 755-768 | 14 | |
| β-strand | 774 | 1 | 34 |
| β-strand | 781 | 1 | 34 |
Chain 5: 29 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-41 | 15 | |
| α-helix | 54-65 | 12 | |
| β-strand | 69-73 | 5 | 35 |
| α-helix | 74-80 | 7 | |
| α-helix | 82-88 | 7 | |
| α-helix | 92-110 | 19 | |
| α-helix | 114-115 | 2 | |
| α-helix | 121-123 | 3 | |
| β-strand | 125-129 | 5 | 35 |
| α-helix | 132-134 | 3 | |
| α-helix | 137-139 | 3 | |
| α-helix | 142-144 | 3 | |
| β-strand | 148-158 | 11 | 15 |
| β-strand | 162-172 | 11 | 15 |
| β-strand | 178-183 | 6 | 15 |
| β-strand | 189 | 1 | 36 |
| β-strand | 191-192 | 2 | 14 |
| β-strand | 212-214 | 3 | 15 |
| α-helix | 216-218 | 3 | |
| β-strand | 220-230 | 11 | 15 |
| α-helix | 237 | 1 | |
| β-strand | 244-250 | 7 | 15 |
| α-helix | 251-253 | 3 | |
| β-strand | 262-271 | 10 | 15 |
| β-strand | 273 | 1 | 36 |
| β-strand | 289 | 1 | 2 |
| β-strand | 292-301 | 10 | 15 |
| α-helix | 317-327 | 11 | |
| α-helix | 331-338 | 8 | |
| α-helix | 347-358 | 12 | |
| β-strand | 363-364 | 2 | 37 |
| β-strand | 370-371 | 2 | 37 |
| β-strand | 377-381 | 5 | 38 |
| α-helix | 388-397 | 10 | |
| β-strand | 401-403 | 3 | 38 |
| β-strand | 411 | 1 | 9 |
| β-strand | 417-420 | 4 | 39 |
| β-strand | 427-430 | 4 | 39 |
| α-helix | 433-436 | 4 | |
| β-strand | 441-444 | 4 | 38 |
| α-helix | 447-449 | 3 | |
| α-helix | 452-463 | 12 | |
| β-strand | 466-471 | 6 | 40 |
| β-strand | 474-479 | 6 | 40 |
| β-strand | 483-486 | 4 | 38 |
| α-helix | 508-511 | 4 | |
| β-strand | 516-520 | 5 | 38 |
| α-helix | 526-542 | 17 | |
| α-helix | 553-555 | 3 | |
| α-helix | 556-569 | 14 | |
| β-strand | 570 | 1 | 20 |
| β-strand | 573 | 1 | 41 |
| α-helix | 576-600 | 25 | |
| α-helix | 610-626 | 17 | |
| β-strand | 631 | 1 | 41 |
| α-helix | 634-644 | 11 | |
| α-helix | 645-649 | 5 | |
| α-helix | 650-653 | 4 | |
Chain 6: 31 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-36 | 16 | |
| α-helix | 45-51 | 7 | |
| α-helix | 52-54 | 3 | |
| β-strand | 60-63 | 4 | 42 |
| α-helix | 65-69 | 5 | |
| α-helix | 73-81 | 9 | |
| α-helix | 83-101 | 19 | |
| β-strand | 111-114 | 4 | 42 |
| β-strand | 121 | 1 | 5 |
| α-helix | 123-125 | 3 | |
| α-helix | 128-130 | 3 | |
| β-strand | 134-143 | 10 | 5 |
| β-strand | 148-153 | 6 | 5 |
| β-strand | 156-158 | 3 | 43 |
| β-strand | 164-165 | 2 | 43 |
| β-strand | 169 | 1 | 5 |
| β-strand | 191-193 | 3 | 43 |
| α-helix | 195-197 | 3 | |
| β-strand | 199-209 | 11 | 5 |
| α-helix | 212-214 | 3 | |
| α-helix | 220-222 | 3 | |
| β-strand | 223-229 | 7 | 5 |
| α-helix | 230-233 | 4 | |
| β-strand | 241-252 | 12 | 5 |
| β-strand | 294-299 | 6 | 5 |
| β-strand | 302-305 | 4 | 5 |
| α-helix | 322-328 | 7 | |
| α-helix | 331-341 | 11 | |
| α-helix | 346-354 | 9 | |
| α-helix | 362-373 | 12 | |
| β-strand | 378-379 | 2 | 44 |
| β-strand | 385-386 | 2 | 44 |
| β-strand | 392-396 | 5 | 45 |
| α-helix | 403-412 | 10 | |
| β-strand | 416-420 | 5 | 45 |
| α-helix | 421-423 | 3 | |
| β-strand | 424 | 1 | 32 |
| β-strand | 431-435 | 5 | 46 |
| β-strand | 442-446 | 5 | 46 |
| α-helix | 448-451 | 4 | |
| β-strand | 456-460 | 5 | 45 |
| α-helix | 467-479 | 13 | |
| β-strand | 481-486 | 6 | 47 |
| β-strand | 489-494 | 6 | 47 |
| β-strand | 498-503 | 6 | 45 |
| α-helix | 516-518 | 3 | |
| α-helix | 524-529 | 6 | |
| β-strand | 532-536 | 5 | 45 |
| α-helix | 542-557 | 16 | |
| α-helix | 569-579 | 11 | |
| β-strand | 585-586 | 2 | 48 |
| α-helix | 588-603 | 16 | |
| α-helix | 610-611 | 2 | |
| β-strand | 612 | 1 | 49 |
| α-helix | 618-634 | 17 | |
| β-strand | 639-640 | 2 | 48 |
| α-helix | 642-654 | 13 | |
| β-strand | 658 | 1 | 49 |
| α-helix | 718-733 | 16 | |
| α-helix | 745-755 | 11 | |
| α-helix | 764-782 | 19 | |
Chain 7: 27 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-17 | 12 | |
| α-helix | 32-41 | 10 | |
| β-strand | 48-51 | 4 | 50 |
| α-helix | 52-55 | 4 | |
| α-helix | 60-68 | 9 | |
| α-helix | 70-88 | 19 | |
| α-helix | 98-108 | 11 | |
| α-helix | 128-131 | 4 | |
| β-strand | 136-139 | 4 | 50 |
| α-helix | 149-151 | 3 | |
| α-helix | 154-156 | 3 | |
| β-strand | 160-170 | 11 | 28 |
| α-helix | 171-173 | 3 | |
| β-strand | 174-184 | 11 | 28 |
| β-strand | 190-194 | 5 | 28 |
| β-strand | 199-200 | 2 | 27 |
| β-strand | 205 | 1 | 51 |
| α-helix | 209-213 | 5 | |
| β-strand | 219 | 1 | 51 |
| β-strand | 220-222 | 3 | 28 |
| β-strand | 228-238 | 11 | 28 |
| α-helix | 245 | 1 | |
| β-strand | 252-258 | 7 | 28 |
| α-helix | 259-261 | 3 | |
| β-strand | 270-280 | 11 | 28 |
| β-strand | 293 | 1 | 12 |
| β-strand | 295-305 | 11 | 28 |
| α-helix | 348-359 | 12 | |
| β-strand | 377-381 | 5 | 52 |
| α-helix | 388-397 | 10 | |
| β-strand | 401-404 | 4 | 52 |
| α-helix | 407-409 | 3 | |
| α-helix | 411-413 | 3 | |
| β-strand | 416-418 | 3 | 53 |
| β-strand | 429-431 | 3 | 53 |
| α-helix | 433-436 | 4 | |
| β-strand | 440-445 | 6 | 52 |
| α-helix | 447-449 | 3 | |
| α-helix | 452-464 | 13 | |
| β-strand | 466-471 | 6 | 30 |
| β-strand | 474-479 | 6 | 30 |
| β-strand | 482-488 | 7 | 52 |
| α-helix | 509-514 | 6 | |
| β-strand | 517-521 | 5 | 52 |
| α-helix | 527-543 | 17 | |
| α-helix | 546-548 | 3 | |
| α-helix | 556-568 | 13 | |
| β-strand | 572 | 1 | 54 |
| α-helix | 578-594 | 17 | |
| α-helix | 603-620 | 18 | |
| β-strand | 624 | 1 | 54 |
| α-helix | 627-641 | 15 | |
Chain F: 12 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-13 | 11 | |
| α-helix | 18-34 | 17 | |
| α-helix | 36-41 | 6 | |
| α-helix | 45-58 | 14 | |
| α-helix | 65-72 | 8 | |
| α-helix | 76-90 | 15 | |
| α-helix | 98-103 | 6 | |
| α-helix | 110-122 | 13 | |
| α-helix | 129-132 | 4 | |
| α-helix | 138-150 | 13 | |
| α-helix | 159-165 | 7 | |
| α-helix | 169-181 | 13 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Origin recognition complex subunit 6 | F | protein | 251 | Homo sapiens | Q9Y5N6 (AlphaFold model) |
| DNA replication licensing factor MCM2 | 2 | protein | 904 | Homo sapiens | P49736 (AlphaFold model) |
| DNA replication licensing factor MCM3 | 3 | protein | 810 | Homo sapiens | P25205 (AlphaFold model) |
| DNA replication licensing factor MCM4 | 4 | protein | 863 | Homo sapiens | P33991 (AlphaFold model) |
| DNA replication licensing factor MCM5 | 5 | protein | 734 | Homo sapiens | P33992 |
| DNA replication licensing factor MCM6 | 6 | protein | 821 | Homo sapiens | Q14566 |
| DNA replication licensing factor MCM7 | 7 | protein | 719 | Homo sapiens | P33993 |
| DNA (45-mer) | X | DNA | 45 | synthetic construct | |
| DNA (45-mer) | Y | DNA | 45 | synthetic construct | |
Sequence of entity 1 (F), FASTA
>8S0B_1 Origin recognition complex subunit 6 (chains F)
GSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKC
PLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSY
ESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEK
IGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILE
NAASAQKATAE
Sequence of entity 2 (2), FASTA
>8S0B_2 DNA replication licensing factor MCM2 (chains 2)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF
Sequence of entity 3 (3), FASTA
>8S0B_3 DNA replication licensing factor MCM3 (chains 3)
GEMAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKN
EKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTS
CFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKD
EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVV
GTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQ
LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYV
LCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQED
QQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLR
SQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
EKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMP
QVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEE
PFSSVEIQAALSKMQDDNQVMVSEGIIFLI
Sequence of entity 4 (4), FASTA
>8S0B_4 DNA replication licensing factor MCM4 (chains 4)
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDR
RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
EEALRALADDDFLTVTGKTVRLL
Sequence of entity 5 (5), FASTA
>8S0B_5 DNA replication licensing factor MCM5 (chains 5)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK
Sequence of entity 6 (6), FASTA
>8S0B_6 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED
Sequence of entity 7 (7), FASTA
>8S0B_7 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
Sequence of entity 8 (X), FASTA
>8S0B_8 DNA (45-mer) (chains X)
CTGACTGACTGAACTATGCATGCATGCGCATGCATGCATGCATGC
Sequence of entity 9 (Y), FASTA
>8S0B_9 DNA (45-mer) (chains Y)
GCATGCATGCATGCATGCGCATGCATGCATAGTTCAGTCAGTCAG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 3 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 3 |
| ZN | Zinc ion | Zn | 5 |
| MG | Magnesium ion | Mg | 6 |
Primary citation
MCM double hexamer loading visualized with human proteins. Weissmann, F., Greiwe, J.F., Puhringer, T. et al. Nature (2024) 636:499-508. DOI 10.1038/s41586-024-08263-6 · PubMed
Other PDB entries of the same protein (UniProt Q9Y5N6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 3M03 2.5 Å, Crystal structure of human Orc6 fragment
- 8S0D 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC1-6
- 6KVG The solution structure of human Orc6
Browse structure collections
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