3MT5: Human BK Gating Apparatus

Crystal Structure of the Human BK Gating Apparatus. Determined by X-ray diffraction at 3.0 Å resolution. Released 9 Jun 2010.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 4,686
Mol. weight: 81.78 kDa
Ligands: CA
Released: 9 Jun 2010

Explore 3MT5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3MT5 contains 42 α-helices and 32 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	344-349	6	1
α-helix	353-366	14
β-strand	374-378	5	1
α-helix	385-388	4
α-helix	391-394	4
β-strand	398-401	4	1
α-helix	408-413	6
α-helix	416-418	3
β-strand	421-425	5	1
α-helix	426	1
α-helix	433-450	18
β-strand	456-460	5	1
α-helix	463-466	4
α-helix	467-471	5
β-strand	482-485	4	1
α-helix	486-499	14
α-helix	503-508	6
α-helix	524-532	9
β-strand	535-540	6	2
α-helix	541-542	2
α-helix	543-545	3
β-strand	549	1	3
α-helix	550-556	7
α-helix	557-561	5
β-strand	564-569	6	2
β-strand	580-581	2	2
β-strand	588	1	3
β-strand	594-599	6	2
α-helix	602-606	5
α-helix	680-682	3
β-strand	686-687	2	4
β-strand	692	1	5
β-strand	693	1	4
α-helix	700-702	3
β-strand	704	1	6
α-helix	707-712	6
β-strand	719-724	6	6
α-helix	730-731	2
α-helix	735-738	4
α-helix	740-742	3
β-strand	743	1	5
α-helix	748-750	3
α-helix	751-753	3
β-strand	754-758	5	6
α-helix	760-770	11
β-strand	776-780	5	6
α-helix	786-791	6
α-helix	794-796	3
β-strand	799-804	6	6
α-helix	818-828	11
β-strand	831-832	2	7
β-strand	871-872	2	7
α-helix	873-875	3
β-strand	878-882	5	6
α-helix	885-888	4
α-helix	903-905	3
α-helix	907-910	4
β-strand	914-916	3	6
α-helix	917-921	5
α-helix	923-929	7
α-helix	931-941	11
α-helix	950-956	7
β-strand	961-962	2	4
α-helix	966-970	5
β-strand	976-981	6	8
α-helix	989-991	3
β-strand	995	1	9
α-helix	996-1006	11
β-strand	1010-1017	8	8
β-strand	1031-1035	5	8
α-helix	1041	1
β-strand	1042	1	9
α-helix	1043	1
β-strand	1048-1053	6	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Potassium large conductance calcium-activated channel, subfamily M, alpha member 1	A	protein	726	Homo sapiens	Q12791 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3MT5_1 Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (chains A)
MGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVE
FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQ
MLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKI
EEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRI
LINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPS
TLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKE
IEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGS
IEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKE
CILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPII
TELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRT
LVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDL
FCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDSNS
LEVLFQ

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Yuan, P., Leonetti, M.D., Pico, A.R. et al. Science (2010) 329:182-186. DOI 10.1126/science.1190414 · PubMed

Other PDB entries of the same protein (UniProt Q12791 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6V5A 2.0 Å, Crystal structure of the human BK channel gating ring L390P mutant
8V60 2.43 Å, F315A mutant of human Slo1 in presence of EDTA - resting VSD
11DA 2.57 Å, Human Slo1-PenitremA complex under divalent chelated condition - full model
9CZM 2.57 Å, Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in nanodisc.
11DC 2.58 Å, Human Slo1-PenitremA complex under divalent chelated condition - gating-ring masked out
11CZ 2.6 Å, Human Slo1-paxilline complex under divalent chelated condition - full model
8V64 2.6 Å, RCK1-RCK2 double mutant of human Slo1 in presence of EDTA - resting VSD
8GHF 2.7 Å, cryo-EM structure of hSlo1 in plasma membrane vesicles
11DB 2.71 Å, Human Slo1-Paxilline complex under divalent chelated condition - gating-ring masked
8V63 2.72 Å, R207A mutant of human Slo1 in presence of EDTA - activated VSD
9JO3 2.8 Å, Cryo-EM structure of human BKca channel-compound 10b complex
8VAZ 2.82 Å, Structure of human Slo1 and human LRRC26 in EDTA - LRRD masked

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