Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide. Determined by X-ray diffraction at 1.6 Å resolution. Released 2 Nov 2011.
Explore 3OV1 in 3D Show helices and sheets RCSB PDB PDBe
3OV1 contains 2 α-helices and 9 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 61 | 1 | 1 |
| α-helix | 67-75 | 9 | |
| β-strand | 82 | 1 | 2 |
| β-strand | 83-87 | 5 | 1 |
| β-strand | 95-101 | 7 | 1 |
| β-strand | 104-109 | 6 | 1 |
| β-strand | 111-112 | 2 | 3 |
| β-strand | 118-119 | 2 | 3 |
| β-strand | 124-125 | 2 | 3 |
| α-helix | 128-134 | 7 | |
| β-strand | 149 | 1 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Growth factor receptor-bound protein 2 | A | protein | 117 | Homo sapiens | P62993 (AlphaFold model) |
| PYAC3CN | B | protein | 5 |
>3OV1_1 Growth factor receptor-bound protein 2 (chains A) IEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR DGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQAHHHHHH
>3OV1_2 PYAC3CN (chains B) XYXNX
Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. Myslinski, J.M., Delorbe, J.E., Clements, J.H. et al. J Am Chem Soc (2011) 133:18518-18521. DOI 10.1021/ja2068752 · PubMed
Other PDB entries of the same protein (UniProt P62993 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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