3SE3: Human IFNa2-IFNAR ternary complex

human IFNa2-IFNAR ternary complex. Determined by X-ray diffraction at 4.0 Å resolution. Released 31 Aug 2011.

Method: X-ray diffraction
Resolution: 4.0 Å
Organism: Homo sapiens
Chains: 3
Atoms: 4,462
Mol. weight: 90.14 kDa
Ligands: NAG
Released: 31 Aug 2011

Explore 3SE3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3SE3 contains 25 α-helices and 47 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	11-12	2	1
β-strand	13-14	2	2
β-strand	19-20	2	1
β-strand	33-38	6	3
β-strand	47-48	2	3
β-strand	55	1	3
β-strand	59	1	1
β-strand	75-81	7	3
β-strand	84-90	7	3
α-helix	95-98	4
β-strand	99-100	2	2
α-helix	101-104	4
β-strand	105-110	6	4
β-strand	115-120	6	4
α-helix	130-135	6
β-strand	137-144	8	5
β-strand	150-156	7	5
β-strand	159-162	4	4
β-strand	170-178	9	5
β-strand	185-188	4	5
α-helix	189-191	3
β-strand	192-195	4	5
α-helix	199-200	2
α-helix	203-205	3
β-strand	209-213	5	6
β-strand	216-220	5	6
β-strand	229-230	2	7
β-strand	233-236	4	8
α-helix	237-241	5
α-helix	250	1
β-strand	251-252	2	8
α-helix	254-256	3
β-strand	259	1	7
β-strand	263-266	4	6
α-helix	268-270	3
β-strand	276-279	4	8
β-strand	281-283	3	7
β-strand	288-291	4	7
α-helix	292-294	3
β-strand	295-297	3	8

Chain B: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	9-20	12
α-helix	27-32	6
α-helix	40-42	3
α-helix	53-66	14
α-helix	70-75	6
α-helix	78-97	20
α-helix	115-132	18
α-helix	137-155	19

Chain C: 6 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	12-18	7	9
β-strand	23-29	7	9
β-strand	38-45	8	10
α-helix	50-52	3
β-strand	53-54	2	10
α-helix	55	1
α-helix	56-58	3
β-strand	61	1	10
β-strand	65-67	3	9
β-strand	78-86	9	10
β-strand	91-100	10	10
α-helix	101-104	4
β-strand	107	1	9
α-helix	108-110	3
β-strand	111-116	6	11
β-strand	121-126	6	11
β-strand	140-147	8	12
β-strand	150-154	5	12
β-strand	166-170	5	11
β-strand	175	1	13
β-strand	179-186	8	12
α-helix	195-198	4
β-strand	199-201	3	12
β-strand	203	1	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interferon alpha/beta receptor 1	A	protein	414	Homo sapiens	P17181 (AlphaFold model)
Interferon alpha 2b	B	protein	166	Homo sapiens	P01563 (AlphaFold model)
Interferon alpha/beta receptor 2	C	protein	199	Homo sapiens	P48551 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3SE3_1 Interferon alpha/beta receptor 1 (chains A)
ADLGSKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNI
TSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAI
VIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKV
KAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWL
HAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEI
KFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAER
KIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSK

Sequence of entity 2 (B), FASTA

>3SE3_2 Interferon alpha 2b (chains B)
MCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLYNM
ISQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAV
RKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE

Sequence of entity 3 (C), FASTA

>3SE3_3 Interferon alpha/beta receptor 2 (chains C)
YTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFC
DLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVK
FPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLE
HSDEQAVIKSPLKCTLLPP

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	1

Primary citation

Structural linkage between ligand discrimination and receptor activation by type I interferons. Thomas, C., Moraga, I., Levin, D. et al. Cell (2011) 146:621-632. DOI 10.1016/j.cell.2011.06.048 · PubMed

Other PDB entries of the same protein (UniProt P17181 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3S98 1.9 Å, human IFNAR1
4PO6 1.99 Å, Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular…
8Y31 2.68 Å, The crystal structure of the QX006N-Fab/IFNAR1-SD123 complex
3SE4 3.5 Å, human IFNw-IFNAR ternary complex

Browse structure collections

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