3SE4: Human IFNw-IFNAR ternary complex

human IFNw-IFNAR ternary complex. Determined by X-ray diffraction at 3.5 Å resolution. Released 31 Aug 2011.

Method: X-ray diffraction
Resolution: 3.5 Å
Organism: Homo sapiens
Chains: 3
Atoms: 4,784
Mol. weight: 91.23 kDa
Ligands: NAG
Released: 31 Aug 2011

Explore 3SE4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3SE4 contains 21 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	11-14	4	1
β-strand	17-20	4	1
β-strand	33-40	8	2
β-strand	47-55	9	2
α-helix	59	1
β-strand	60-61	2	1
β-strand	73-81	9	2
β-strand	84-89	6	2
β-strand	93	1	2
α-helix	95-98	4
β-strand	105-110	6	3
β-strand	115-120	6	3
α-helix	130-133	4
β-strand	137-144	8	4
β-strand	150-156	7	4
β-strand	159-162	4	3
β-strand	170-178	9	4
β-strand	185-188	4	4
α-helix	189-191	3
β-strand	192-195	4	4
α-helix	196-197	2
α-helix	203-205	3
β-strand	206-213	8	5
β-strand	216-222	7	5
β-strand	229-236	8	6
α-helix	238-240	3
α-helix	251	1
β-strand	252	1	6
α-helix	253	1
β-strand	259	1	6
β-strand	263-267	5	5
α-helix	268-270	3
β-strand	275-283	9	6
β-strand	288-291	4	6
α-helix	292-294	3
β-strand	295-298	4	6

Chain B: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	10-22	13
α-helix	28-31	4
α-helix	52-70	19
α-helix	75-77	3
α-helix	81-98	18
α-helix	118-136	19
α-helix	140-157	18

Chain C: 3 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	11-19	9	7
β-strand	22-30	9	7
β-strand	38-45	8	8
β-strand	53-54	2	8
β-strand	61	1	8
β-strand	65-66	2	7
β-strand	78-86	9	8
β-strand	91-100	10	8
α-helix	101-104	4
β-strand	106-107	2	7
β-strand	111-113	3	9
β-strand	116	1	9
β-strand	121-126	6	9
β-strand	140-146	7	10
β-strand	151-154	4	10
β-strand	165-170	6	9
α-helix	173-174	2
β-strand	178-186	9	10
α-helix	194-198	5
β-strand	199-202	4	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interferon alpha/beta receptor 1	A	protein	414	Homo sapiens	P17181 (AlphaFold model)
Interferon omega-1	B	protein	177	Homo sapiens	P05000 (AlphaFold model)
Interferon alpha/beta receptor 2	C	protein	199	Homo sapiens	P48551 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3SE4_1 Interferon alpha/beta receptor 1 (chains A)
ADLGSKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNI
TSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAI
VIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKV
KAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWL
HAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEI
KFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAER
KIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSK

Sequence of entity 2 (B), FASTA

>3SE4_2 Interferon omega-1 (chains B)
ADPLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFRFPQEMVKGSQLQKAHVMS
VLHEMLQQIFSLFHTERSSAAWQMTLLDQLHTGLHQQLQHLETCLLQVVGEGESAGAISS
PALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTNMQERLRSKDRDLGSS

Sequence of entity 3 (C), FASTA

>3SE4_3 Interferon alpha/beta receptor 2 (chains C)
YTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFC
DLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVK
FPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLE
HSDEQAVIKSPLKCTLLPP

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	1

Primary citation

Structural linkage between ligand discrimination and receptor activation by type I interferons. Thomas, C., Moraga, I., Levin, D. et al. Cell (2011) 146:621-632. DOI 10.1016/j.cell.2011.06.048 · PubMed

Other PDB entries of the same protein (UniProt P17181 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3S98 1.9 Å, human IFNAR1
4PO6 1.99 Å, Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular…
8Y31 2.68 Å, The crystal structure of the QX006N-Fab/IFNAR1-SD123 complex
3SE3 4.0 Å, human IFNa2-IFNAR ternary complex

Browse structure collections

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