3TGX: IL-21:IL21R complex
IL-21:IL21R complex. Determined by X-ray diffraction at 2.8 Å resolution. Released 15 Feb 2012.
- Method
- X-ray diffraction
- Resolution
- 2.8 Å
- Organism
- Homo sapiens
- Chains
- 16
- Atoms
- 21,830
- Mol. weight
- 343.28 kDa
- Ligands
- NI, MAN
- Released
- 15 Feb 2012
Explore 3TGX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
3TGX contains 145 α-helices and 172 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 8 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-8 | 5 | 1 |
| β-strand | 13-19 | 7 | 1 |
| α-helix | 25-26 | 2 | |
| β-strand | 27-32 | 6 | 2 |
| β-strand | 45-48 | 4 | 2 |
| β-strand | 49-53 | 5 | 1 |
| β-strand | 57-63 | 7 | 1 |
| α-helix | 66-68 | 3 | |
| β-strand | 74-80 | 7 | 2 |
| β-strand | 87-94 | 8 | 2 |
| α-helix | 95-97 | 3 | |
| β-strand | 99 | 1 | 1 |
| α-helix | 101-104 | 4 | |
| β-strand | 105-112 | 8 | 3 |
| β-strand | 114-120 | 7 | 3 |
| α-helix | 122-124 | 3 | |
| α-helix | 126-131 | 6 | |
| β-strand | 135-143 | 9 | 4 |
| α-helix | 151-152 | 2 | |
| β-strand | 153-157 | 5 | 4 |
| β-strand | 163-166 | 4 | 3 |
| β-strand | 176-185 | 10 | 4 |
| β-strand | 193 | 1 | 1 |
| α-helix | 195-201 | 7 | |
| β-strand | 202-205 | 4 | 4 |
Chain B: 9 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-20 | 18 | |
| α-helix | 21-26 | 6 | |
| β-strand | 27 | 1 | 5 |
| β-strand | 32-33 | 2 | 6 |
| α-helix | 40-42 | 3 | |
| α-helix | 43-52 | 10 | |
| β-strand | 57 | 1 | 5 |
| α-helix | 58 | 1 | |
| α-helix | 63-74 | 12 | |
| α-helix | 77-80 | 4 | |
| α-helix | 100 | 1 | |
| β-strand | 101-102 | 2 | 6 |
| α-helix | 104-120 | 17 | |
Chain C: 9 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-8 | 5 | 7 |
| β-strand | 13-19 | 7 | 7 |
| α-helix | 25-26 | 2 | |
| β-strand | 27-32 | 6 | 8 |
| β-strand | 45-48 | 4 | 8 |
| β-strand | 49-53 | 5 | 7 |
| β-strand | 57-63 | 7 | 7 |
| α-helix | 66-68 | 3 | |
| β-strand | 74-80 | 7 | 8 |
| β-strand | 87-94 | 8 | 8 |
| α-helix | 95-97 | 3 | |
| β-strand | 99 | 1 | 7 |
| α-helix | 101-104 | 4 | |
| β-strand | 105-112 | 8 | 9 |
| β-strand | 114-120 | 7 | 9 |
| α-helix | 122-124 | 3 | |
| α-helix | 126-131 | 6 | |
| β-strand | 135-143 | 9 | 10 |
| α-helix | 151-152 | 2 | |
| β-strand | 153-157 | 5 | 10 |
| β-strand | 163-166 | 4 | 9 |
| α-helix | 168-170 | 3 | |
| β-strand | 176-185 | 10 | 10 |
| β-strand | 193 | 1 | 7 |
| α-helix | 195-201 | 7 | |
| β-strand | 202-205 | 4 | 10 |
Chain D: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-20 | 17 | |
| α-helix | 21-26 | 6 | |
| β-strand | 27 | 1 | 11 |
| β-strand | 32-33 | 2 | 12 |
| α-helix | 43-52 | 10 | |
| β-strand | 57 | 1 | 11 |
| α-helix | 64-74 | 11 | |
| α-helix | 77-80 | 4 | |
| α-helix | 93-95 | 3 | |
| α-helix | 100 | 1 | |
| β-strand | 101-102 | 2 | 12 |
| α-helix | 104-121 | 18 | |
Chain E: 8 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-8 | 5 | 13 |
| β-strand | 13-19 | 7 | 13 |
| α-helix | 25-26 | 2 | |
| β-strand | 27-32 | 6 | 14 |
| β-strand | 45-48 | 4 | 14 |
| β-strand | 49-53 | 5 | 13 |
| β-strand | 57-63 | 7 | 13 |
| α-helix | 66-68 | 3 | |
| β-strand | 74-80 | 7 | 14 |
| β-strand | 87-94 | 8 | 14 |
| α-helix | 95-97 | 3 | |
| β-strand | 99 | 1 | 13 |
| α-helix | 101-104 | 4 | |
| β-strand | 105-112 | 8 | 15 |
| β-strand | 114-120 | 7 | 15 |
| α-helix | 122-124 | 3 | |
| α-helix | 126-131 | 6 | |
| β-strand | 135-143 | 9 | 16 |
| β-strand | 147 | 1 | 17 |
| α-helix | 151-152 | 2 | |
| β-strand | 153-156 | 4 | 16 |
| β-strand | 163-166 | 4 | 15 |
| β-strand | 176 | 1 | 18 |
| β-strand | 177-185 | 9 | 16 |
| β-strand | 193 | 1 | 13 |
| α-helix | 197-201 | 5 | |
| β-strand | 202 | 1 | 16 |
| β-strand | 205 | 1 | 18 |
Chain F: 9 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-19 | 17 | |
| α-helix | 20-26 | 7 | |
| β-strand | 27 | 1 | 19 |
| β-strand | 32-33 | 2 | 20 |
| α-helix | 43-52 | 10 | |
| β-strand | 57 | 1 | 19 |
| α-helix | 58 | 1 | |
| α-helix | 63-74 | 12 | |
| α-helix | 77-80 | 4 | |
| α-helix | 96-98 | 3 | |
| α-helix | 100 | 1 | |
| β-strand | 101-102 | 2 | 20 |
| α-helix | 104-120 | 17 | |
Chain G: 10 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-8 | 5 | 21 |
| β-strand | 13-19 | 7 | 21 |
| α-helix | 25-26 | 2 | |
| β-strand | 27-32 | 6 | 22 |
| β-strand | 45-48 | 4 | 22 |
| β-strand | 49-53 | 5 | 21 |
| β-strand | 57-63 | 7 | 21 |
| α-helix | 66-68 | 3 | |
| β-strand | 74-80 | 7 | 22 |
| β-strand | 87-94 | 8 | 22 |
| α-helix | 95-97 | 3 | |
| β-strand | 99 | 1 | 21 |
| α-helix | 101-104 | 4 | |
| β-strand | 105-112 | 8 | 23 |
| β-strand | 114-120 | 7 | 23 |
| α-helix | 122-124 | 3 | |
| α-helix | 126-131 | 6 | |
| β-strand | 135-143 | 9 | 24 |
| α-helix | 151-152 | 2 | |
| β-strand | 153-157 | 5 | 24 |
| β-strand | 163-166 | 4 | 23 |
| α-helix | 168-170 | 3 | |
| β-strand | 176-185 | 10 | 24 |
| β-strand | 193 | 1 | 21 |
| α-helix | 197-201 | 5 | |
| β-strand | 202-205 | 4 | 24 |
| α-helix | 206-208 | 3 | |
Chain H: 10 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| α-helix | 21-26 | 6 | |
| β-strand | 27 | 1 | 25 |
| β-strand | 32-33 | 2 | 26 |
| α-helix | 40-42 | 3 | |
| α-helix | 43-52 | 10 | |
| β-strand | 57 | 1 | 25 |
| α-helix | 58 | 1 | |
| α-helix | 63-74 | 12 | |
| α-helix | 77-80 | 4 | |
| α-helix | 96-98 | 3 | |
| α-helix | 100 | 1 | |
| β-strand | 101-102 | 2 | 26 |
| α-helix | 104-120 | 17 | |
8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Interleukin-21 receptor | A, C, E, G, I, K, M, O | protein | 219 | Homo sapiens | Q9HBE5 (AlphaFold model) |
| Interleukin-21 | B, D, F, H, J, L, N, P | protein | 134 | Homo sapiens | Q9HBE4 (AlphaFold model) |
Sequence of entity 1 (A, C, E, G, I, K, M, O), FASTA
>3TGX_1 Interleukin-21 receptor (chains A, C, E, G, I, K, M, O)
CPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATY
TCHMDVFHFMADDIFSVQITDQSGQYSQECGSFLLAESIKPAPPFDVTVTFSGQYQISWR
SDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQ
VRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEHHHHHH
Sequence of entity 2 (B, D, F, H, J, L, N, P), FASTA
>3TGX_2 Interleukin-21 (chains B, D, F, H, J, L, N, P)
MQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSAN
TGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMI
HQHLSSRTHGSEDS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| NI | Nickel (II) ion | Ni | 4 |
| MAN | alpha-D-mannopyranose | C6 H12 O6 | 8 |
Water and common crystallization additives (SO4) are not listed.
Primary citation
The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor. Hamming, O.J., Kang, L., Svensson, A. et al. J Biol Chem (2012). DOI 10.1074/jbc.M111.311084 · PubMed
Other PDB entries of the same protein (UniProt Q9HBE5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6PLH 1.6 Å, FAB fragment complexed with C-mannosylated tryptophan peptide
- 7KQ7 2.2 Å, Crystal structure of IL21R in complex with an antibody Fab fragment
- 9E2T 2.28 Å, Structure of a de novo designed interleukin-21 mimetic complex with IL-21R and IL-2Rg
- 4NZD 2.75 Å, Interleukin 21 receptor
- 8ENT 2.83 Å, Interleukin-21 signaling complex with IL-21R and IL-2Rg
Browse structure collections
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