3TJ3: Importin a5

Structure of importin a5 bound to the N-terminus of Nup50. Determined by X-ray diffraction at 2.7 Å resolution. Released 30 Nov 2011.

Method
X-ray diffraction
Resolution
2.7 Å
Organism
Homo sapiens
Chains
4
Atoms
7,545
Mol. weight
122.41 kDa
Released
30 Nov 2011

Explore 3TJ3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3TJ3 contains 73 α-helices and 6 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 32 helices, 1 β-strand

ElementResiduesLengthSheet
α-helix85-928
α-helix96-11015
α-helix118-1236
α-helix127-1348
α-helix141-15515
α-helix159-1679
α-helix170-1778
α-helix183-19715
α-helix201-2099
α-helix213-2208
α-helix226-24015
α-helix246-2483
α-helix249-2524
α-helix253-2553
α-helix256-2627
α-helix268-28114
α-helix286-2949
α-helix298-3047
α-helix310-32314
α-helix328-3358
α-helix339-3468
α-helix352-36514
α-helix370-3789
α-helix382-3887
α-helix394-41017
α-helix413-4219
α-helix425-4295
α-helix437-45923
α-helix468-4736
α-helix477-4837
α-helix484-4863
β-strand48711
α-helix490-50314
Chain B: 32 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix85-928
α-helix96-11015
α-helix118-1236
α-helix127-1348
α-helix141-15515
α-helix159-16810
α-helix170-1778
α-helix183-19715
α-helix201-2099
α-helix213-2208
α-helix226-24015
α-helix246-2483
α-helix249-2524
α-helix253-2553
α-helix256-2627
α-helix268-28114
α-helix286-2949
α-helix298-3047
α-helix310-32314
α-helix328-3358
α-helix339-3468
α-helix352-36514
α-helix370-3789
α-helix382-3887
α-helix394-41017
α-helix413-4219
α-helix425-4295
α-helix437-45923
α-helix467-4737
α-helix477-4837
α-helix484-4863
β-strand48712
α-helix490-50314
β-strand50613
Chain C: 5 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix27-282
β-strand2911
α-helix30-312
α-helix32-376
α-helix39-402
α-helix43-453
Chain D: 4 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix27-282
β-strand2912
α-helix30-312
α-helix32-376
α-helix39-402
β-strand4313

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin subunit alpha-1A, Bprotein447Homo sapiensP52294 (AlphaFold model)
Nuclear pore complex protein Nup50C, Dprotein114Homo sapiensQ9UKX7 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>3TJ3_1 Importin subunit alpha-1 (chains A, B)
GFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTP
GVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDV
QEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSP
PPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL
MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNI
TAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCI
KPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQ
SHENQEIYQKAFDLIEHYFGTEDEDSS
Sequence of entity 2 (C, D), FASTA
>3TJ3_2 Nuclear pore complex protein Nup50 (chains C, D)
GPLGSMAKRNAEKELTDRNWDQEDEAEEVGTFSMASEEVLKNRAIKKAKRRNVGFESDTG
GAFKGFKGLVVPSGGGRFSGFGSGAGGKPLEGLSNGNNITSAPPFASAKAAADP

Primary citation

Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin alpha 5. Pumroy, R.A., Nardozzi, J.D., Hart, D.J. et al. J Biol Chem (2012) 287:2022-2031. DOI 10.1074/jbc.M111.315838 · PubMed

Other PDB entries of the same protein (UniProt P52294 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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