3U7X: Human eIF4E-4EBP1 peptide complex without cap

Name: PDB 3U7X: Crystal structure of the human eIF4E-4EBP1 peptide complex without cap
Published: 2011-11-02
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: translation

Crystal structure of the human eIF4E-4EBP1 peptide complex without cap. Determined by X-ray diffraction at 2.1 Å resolution. Released 2 Nov 2011.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,448
Mol. weight: 55.36 kDa
Released: 2 Nov 2011

Explore 3U7X in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3U7X contains 23 α-helices and 16 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	1
α-helix	56-59	4
β-strand	60-68	9	1
α-helix	69-78	10
α-helix	82-84	3
α-helix	86	1
β-strand	89-95	7	1
β-strand	111-117	7	1
α-helix	119-121	3
α-helix	122-126	5
α-helix	127-138	12
α-helix	143-148	6
β-strand	149-155	7	1
β-strand	161-167	7	1
α-helix	173-187	15
β-strand	196-199	4	1
α-helix	200-205	6
α-helix	211-213	3
β-strand	215-216	2	1

Chain B: 10 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	38-49	12	2
β-strand	60-68	9	2
α-helix	69-78	10
α-helix	82-84	3
α-helix	86	1
β-strand	89-95	7	2
β-strand	111-117	7	2
α-helix	119-121	3
α-helix	122-126	5
α-helix	127-138	12
α-helix	143-148	6
β-strand	149-155	7	2
β-strand	161-167	7	2
α-helix	173-187	15
β-strand	196-199	4	2
α-helix	200-205	6
α-helix	211-213	3
β-strand	215-216	2	2

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	56-61	6

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	56-60	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eukaryotic translation initiation factor 4E	A, B	protein	217	Homo sapiens	P06730 (AlphaFold model)
Eukaryotic translation initiation factor 4E-binding protein 1	C, D	protein	20	Homo sapiens	Q13541 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3U7X_1 Eukaryotic translation initiation factor 4E (chains A, B)
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

Sequence of entity 2 (C, D), FASTA

>3U7X_2 Eukaryotic translation initiation factor 4E-binding protein 1 (chains C, D)
PGGTRIIYDRKFLMECRNSP

Primary citation

Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. Siddiqui, N., Tempel, W., Nedyalkova, L. et al. J Mol Biol (2012) 415:781-792. DOI 10.1016/j.jmb.2011.12.002 · PubMed

Other PDB entries of the same protein (UniProt P06730 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4TPW 1.5 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5T46 1.53 Å, Crystal structure of the human eIF4E-eIF4G complex
8QM8 1.58 Å, Potential drug binding sites for translation initiation factor eIF4E
4TQB 1.59 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5ZJY 1.59 Å, Stapled-peptides tailored against initiation of translation
7D6Y 1.67 Å, eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
5ZJZ 1.67 Å, Stapled-peptides tailored against initiation of translation
5EI3 1.71 Å, Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
4UED 1.75 Å, Complex of human eIF4E with the 4E binding protein 4E-BP1
5ZK9 1.76 Å, Stapled-peptides tailored against initiation of translation
4TQC 1.8 Å, The co-complex structure of the translation initiation factor eIF4E with the inhibitor…
5ZML 1.8 Å, Stapled-peptides tailored against initiation of translation

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