3W3V: Kap121p mutant D353K/E396K/D438K

Crystal structure of Kap121p mutant D353K/E396K/D438K. Determined by X-ray diffraction at 3.2 Å resolution. Released 10 Apr 2013.

Method
X-ray diffraction
Resolution
3.2 Å
Organism
Saccharomyces cerevisiae
Chains
1
Atoms
7,841
Mol. weight
119.94 kDa
Released
10 Apr 2013

Explore 3W3V in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3W3V contains 70 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 70 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix6-1914
α-helix25-3713
α-helix44-5714
α-helix61-7717
α-helix91-933
α-helix96-11116
α-helix116-12712
α-helix135-1362
α-helix138-14912
α-helix153-16513
α-helix168-1725
α-helix175-18713
α-helix191-20717
α-helix210-2156
α-helix217-2193
α-helix220-2256
α-helix228-2325
α-helix236-25217
α-helix254-2574
α-helix261-27313
α-helix279-29517
α-helix297-3015
α-helix304-31714
α-helix329-3324
α-helix343-37634
α-helix381-39414
α-helix399-4024
α-helix406-4138
α-helix414-4185
α-helix422-43817
α-helix442-45918
α-helix465-47915
α-helix484-4874
α-helix488-4903
α-helix491-50212
α-helix507-52418
α-helix525-5284
α-helix529-54416
α-helix551-56818
α-helix570-5734
α-helix577-58812
α-helix596-61318
α-helix614-6207
α-helix621-63111
β-strand638-64031
α-helix644-6463
α-helix649-6513
β-strand656-66161
β-strand663-66751
α-helix669-68921
α-helix690-6934
α-helix694-7007
α-helix701-7055
α-helix706-7083
α-helix715-73521
α-helix742-76019
α-helix764-78118
α-helix788-80922
α-helix830-84920
α-helix853-8586
α-helix861-8688
α-helix873-88816
α-helix895-90915
α-helix914-93017
α-helix936-94914
α-helix961-97717
α-helix987-9937
α-helix1002-101716
α-helix1029-104113
α-helix1053-106210
α-helix1066-10705
α-helix1071-10744
α-helix1078-10858

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin subunit beta-3Aprotein1078Saccharomyces cerevisiaeP32337 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>3W3V_1 Importin subunit beta-3 (chains A)
MSALPEEVNRTLLQIVQAFASPDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQD
TTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQ
DDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASD
NVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVE
LAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLV
MVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALKRVALKLGGEYLAAPLFQY
LQQMITSTEWRERFAAMMALSSAAKGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNV
LGQISTKFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYL
DSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNNKDNS
VLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDIDEDDALRSYLEQSWSRICR
ILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSV
LDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSC
LLAATGTQNEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQL
AAFTKGVSANLTDTYERMQDRHGDGDEYNENIDEEEDFTDEDLLDEINKSIAAVLKTTNG
HYLKNLENIWPMINTFLLDNEPILVIFALVVIGDLIQYGGEQTASMKNAFIPKVTECLIS
PDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDFPGSKLEENRSSTENASAAI
AKILYAYNSNIPNVDTYTANWFKTLPTITDKEAASFNYQFLSQLIENNSPIVCAQSNISA
VVDSVIQALNERSLTEREGQTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA

Primary citation

Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p. Kobayashi, J., Matsuura, Y. J Mol Biol (2013) 425:1852-1868. DOI 10.1016/j.jmb.2013.02.035 · PubMed

Other PDB entries of the same protein (UniProt P32337 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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