3WWQ: FAAP20 UBZ domain

Crystal structure of FAAP20 UBZ domain in complex with Lys63-linked diubiquitin. Determined by X-ray diffraction at 1.9 Å resolution. Released 13 May 2015.

Method: X-ray diffraction
Resolution: 1.9 Å
Organisms: Mus musculus, Homo sapiens
Chains: 12
Atoms: 6,359
Mol. weight: 88.85 kDa
Ligands: ZN
Released: 13 May 2015

Explore 3WWQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3WWQ contains 35 α-helices and 64 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, D, E, G, H and K: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	12-16	5	1
β-strand	22	1	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	1
β-strand	48-49	2	1
α-helix	50-51	2
β-strand	55	1	2
α-helix	57-59	3
β-strand	66-71	6	1

Chain B: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	3
β-strand	12-16	5	3
β-strand	22	1	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	3
β-strand	48-49	2	3
α-helix	50-51	2
β-strand	55	1	4
β-strand	66-71	6	3

Chains C, F, I and L: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	146	1	5
β-strand	153	1	5
α-helix	160-173	14

Chain J: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	16
β-strand	12-16	5	16
β-strand	22	1	17
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	16
β-strand	48-49	2	16
α-helix	50-51	2
β-strand	55	1	17
α-helix	57-59	3
β-strand	66-71	6	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin	A, D, G, J	protein	76	Mus musculus	P0CG50 (AlphaFold model)
Ubiquitin	B, E, H, K	protein	77	Mus musculus	P0CG50 (AlphaFold model)
Fanconi anemia-associated protein of 20 kDa	C, F, I, L	protein	44	Homo sapiens	Q6NZ36 (AlphaFold model)

Sequence of entity 1 (A, D, G, J), FASTA

>3WWQ_1 Ubiquitin (chains A, D, G, J)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQRESTLHLVLRLRGG

Sequence of entity 2 (B, E, H, K), FASTA

>3WWQ_2 Ubiquitin (chains B, E, H, K)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGGD

Sequence of entity 3 (C, F, I, L), FASTA

>3WWQ_3 Fanconi anemia-associated protein of 20 kDa (chains C, F, I, L)
GPGHMAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Primary citation

Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20. Toma, A., Takahashi, T.S., Sato, Y. et al. PLoS One (2015) 10:e0120887-e0120887. DOI 10.1371/journal.pone.0120887 · PubMed

Other PDB entries of the same protein (UniProt P0CG50 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3A9J 1.18 Å, Crystal structure of the mouse TAB2-NZF in complex with Lys63-linked di-ubiquitin
3A9K 1.4 Å, Crystal structure of the mouse TAB3-NZF in complex with Lys63-linked di-ubiquitin
2ZNV 1.6 Å, Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer
3A1Q 2.2 Å, Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin
4NQL 2.3 Å, The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in…
6N5M 3.01 Å, Crystal structure of ABIN-1 UBAN in complex with one M1-linked di-ubiquitin
3WXG 3.1 Å, Crystal structure of CYLD USP domain (C596A) in complex with Lys63-linked diubiquitin
9T67 7.7 Å, Cytoplasmic lattice filament repeat unit with ubiquitin
9T68 8.0 Å, Composite structure of the repeat unit of cytoplasmic lattice filament

Browse structure collections

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