9T67: KH domain-containing protein 3

Cytoplasmic lattice filament repeat unit with ubiquitin. Determined by electron microscopy at 7.7 Å resolution. Released 12 Aug 2026.

Method: Electron microscopy
Resolution: 7.7 Å
Organism: Mus musculus
Chains: 70
Atoms: 181,130
Mol. weight: 4499.19 kDa
Released: 12 Aug 2026

Explore 9T67 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T67 contains 1,525 α-helices and 2,260 β-strands across 70 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 6 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
β-strand	13-16	4	2
β-strand	20-23	4	2
α-helix	27-30	4
α-helix	35-39	5
β-strand	42-46	5	3
α-helix	48-54	7
α-helix	62-69	8
β-strand	72-76	5	3
β-strand	77	1	1
α-helix	83	1
β-strand	84-89	6	3
α-helix	92-135	44

Chain 1: 23 helices, 52 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	30
β-strand	19-20	2	31
β-strand	25-28	4	32
β-strand	39-44	6	30
β-strand	48-52	5	32
β-strand	55-59	5	32
β-strand	63-68	6	30
β-strand	74-79	6	32
β-strand	89-96	8	30
β-strand	106-111	6	30
β-strand	113-114	2	31
β-strand	115-119	5	33
α-helix	134-138	5
β-strand	149-151	3	34
β-strand	153	1	33
α-helix	165-169	5
β-strand	179-186	8	33
α-helix	189-193	5
β-strand	195-200	6	34
α-helix	203-207	5
β-strand	209-214	6	33
β-strand	221-225	5	33
β-strand	226	1	35
β-strand	229	1	35
β-strand	231-233	3	34
β-strand	243-249	7	33
β-strand	260-269	10	34
β-strand	279-280	2	34
β-strand	284-290	7	34
α-helix	291-293	3
β-strand	294	1	36
α-helix	301	1
β-strand	302	1	37
β-strand	306-307	2	38
α-helix	314-327	14
β-strand	333	1	38
α-helix	344-348	5
β-strand	349-354	6	36
β-strand	361-366	6	36
α-helix	377-381	5
β-strand	390	1	36
α-helix	404-406	3
β-strand	408-409	2	39
β-strand	413-415	3	40
β-strand	418-420	3	40
β-strand	424-427	4	39
β-strand	429	1	41
β-strand	439	1	41
α-helix	442-449	8
β-strand	455-458	4	39
β-strand	464	1	42
α-helix	469-471	3
β-strand	473-477	5	43
β-strand	488-494	7	43
α-helix	495-505	11
α-helix	506-510	5
α-helix	521-527	7
α-helix	534-539	6
α-helix	541-565	25
β-strand	572-576	5	43
β-strand	579-583	5	42
α-helix	589-591	3
β-strand	596-600	5	42
α-helix	603-604	2
β-strand	609-611	3	44
β-strand	614-618	5	44
β-strand	624	1	45
β-strand	629	1	45
α-helix	630-642	13
β-strand	645-649	5	44
α-helix	652-656	5
β-strand	666-667	2	38
β-strand	670	1	37
α-helix	671-673	3
α-helix	677-679	3

Chain 2: 29 helices, 59 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	61
β-strand	6-8	3	62
β-strand	15-16	2	63
β-strand	18	1	61
β-strand	19-20	2	64
β-strand	21	1	62
β-strand	24-28	5	62
β-strand	39-44	6	63
β-strand	48-51	4	62
β-strand	56-58	3	62
β-strand	65-68	4	63
β-strand	74-79	6	62
β-strand	89-96	8	63
β-strand	103-111	9	63
β-strand	113-114	2	64
β-strand	115-119	5	65
α-helix	129-131	3
α-helix	134-138	5
β-strand	151	1	66
β-strand	153	1	65
α-helix	157-159	3
α-helix	165-169	5
β-strand	170	1	65
α-helix	171-172	2
α-helix	175-177	3
β-strand	179-186	8	65
α-helix	189-193	5
β-strand	195-200	6	67
α-helix	203-208	6
β-strand	209-213	5	65
β-strand	222-225	4	65
β-strand	226	1	68
β-strand	229	1	68
β-strand	231-233	3	67
α-helix	234-237	4
β-strand	242-249	8	65
β-strand	260-269	10	67
β-strand	273	1	69
β-strand	276	1	69
β-strand	279-280	2	67
β-strand	284-289	6	67
β-strand	290	1	66
α-helix	291-292	2
β-strand	293-295	3	70
α-helix	301	1
β-strand	302-308	7	71
α-helix	311-313	3
α-helix	314-326	13
β-strand	331-334	4	71
α-helix	344-348	5
β-strand	349-355	7	70
β-strand	360-366	7	70
α-helix	378-381	4
α-helix	383	1
β-strand	387-390	4	70
α-helix	404-406	3
β-strand	408-409	2	72
β-strand	413-415	3	73
β-strand	418-420	3	73
β-strand	425-426	2	72
β-strand	429	1	74
α-helix	442-449	8
β-strand	460	1	74
β-strand	464	1	75
α-helix	469-471	3
β-strand	473-477	5	76
β-strand	488-493	6	76
α-helix	495-508	14
β-strand	514	1	77
α-helix	521-527	7
β-strand	533	1	77
α-helix	534-539	6
α-helix	541-565	25
β-strand	572-575	4	76
β-strand	579-583	5	75
β-strand	596-600	5	75
β-strand	609-611	3	78
β-strand	614-618	5	78
β-strand	624-625	2	79
β-strand	628-629	2	79
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-649	5	78
α-helix	652-656	5
α-helix	657-658	2
β-strand	665-670	6	71
α-helix	671-673	3
α-helix	677-679	3

Chain 3: 27 helices, 54 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	107
β-strand	6-8	3	108
β-strand	15-16	2	109
β-strand	18	1	107
β-strand	19-20	2	110
β-strand	25-28	4	108
β-strand	39-44	6	109
β-strand	49-52	4	108
β-strand	55-57	3	108
α-helix	59-61	3
β-strand	65-68	4	109
β-strand	74-78	5	108
β-strand	89-96	8	109
β-strand	105-111	7	109
β-strand	113-114	2	110
β-strand	115-119	5	111
α-helix	134-138	5
β-strand	149-151	3	112
β-strand	153	1	111
α-helix	166-169	4
α-helix	175-177	3
β-strand	179-186	8	111
α-helix	189-193	5
β-strand	195-200	6	112
α-helix	203-207	5
β-strand	209-213	5	111
β-strand	222-225	4	111
β-strand	226	1	113
β-strand	229	1	113
β-strand	231-234	4	112
β-strand	242-249	8	111
β-strand	254	1	114
β-strand	257	1	114
β-strand	260-269	10	112
α-helix	270-271	2
β-strand	279-290	12	112
β-strand	294	1	115
α-helix	295-297	3
α-helix	301	1
β-strand	302-308	7	116
α-helix	311-313	3
α-helix	314-326	13
β-strand	330-334	5	116
α-helix	344-348	5
β-strand	349-356	8	115
β-strand	359-366	8	115
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	115
β-strand	408-409	2	117
β-strand	413-414	2	118
β-strand	419-420	2	118
β-strand	425-429	5	117
α-helix	442-451	10
β-strand	457-460	4	117
β-strand	464	1	119
α-helix	469-471	3
β-strand	473-477	5	120
β-strand	488-493	6	120
α-helix	495-507	13
α-helix	509-512	4
β-strand	514	1	121
α-helix	521-527	7
β-strand	533	1	121
α-helix	534-539	6
α-helix	541-565	25
β-strand	572-575	4	120
β-strand	579-583	5	119
β-strand	596-600	5	119
β-strand	609-611	3	122
β-strand	614-618	5	122
β-strand	624-625	2	123
β-strand	628-629	2	123
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-649	5	122
α-helix	653-656	4
α-helix	657-658	2
β-strand	665-670	6	116
α-helix	671-673	3
α-helix	677-679	3

Chain 4: 43 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	98-108	11
α-helix	114-116	3
α-helix	120-128	9
β-strand	140-144	5	142
β-strand	145	1	143
α-helix	151-163	13
β-strand	175-177	3	142
β-strand	187	1	144
α-helix	190-197	8
α-helix	201-207	7
β-strand	216-220	5	142
α-helix	223-228	6
β-strand	245	1	144
α-helix	246-255	10
β-strand	263-267	5	142
β-strand	269	1	143
α-helix	273-276	4
β-strand	283-289	7	142
α-helix	293-303	11
α-helix	310-319	10
α-helix	321-327	7
α-helix	330-345	16
α-helix	357-372	16
α-helix	378-380	3
α-helix	381-400	20
β-strand	406	1	145
α-helix	407-412	6
α-helix	417-424	8
β-strand	431-432	2	145
β-strand	439-440	2	145
α-helix	445-459	15
α-helix	465-467	3
α-helix	486-498	13
α-helix	501-511	11
α-helix	518-531	14
α-helix	539-551	13
α-helix	555-561	7
β-strand	566-571	6	146
α-helix	575-585	11
β-strand	591-592	2	146
β-strand	593	1	147
β-strand	594-597	4	146
α-helix	624-638	15
β-strand	644-646	3	147
β-strand	651	1	148
α-helix	654-664	11
β-strand	673-675	3	147
β-strand	680	1	148
α-helix	682-684	3
α-helix	685-694	10
β-strand	700	1	147
β-strand	703-704	2	147
α-helix	710-721	12
β-strand	729-733	5	147
α-helix	739-750	12
β-strand	757-761	5	147
α-helix	767-777	11
β-strand	786-790	5	147
α-helix	796-806	11
β-strand	814-816	3	147
α-helix	824-835	12
β-strand	845	1	147
α-helix	853-864	12
β-strand	871-873	3	147
α-helix	881-891	11
β-strand	900-902	3	147
α-helix	912-922	11
β-strand	928-931	4	147
α-helix	937-950	14
β-strand	957-960	4	147
β-strand	961	1	149
α-helix	967-978	12
β-strand	985-987	3	150
β-strand	989	1	149
α-helix	995-1006	12
β-strand	1014-1016	3	150
α-helix	1019-1021	3
α-helix	1024-1036	13
β-strand	1041-1043	3	150

Chain 5: 5 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	158-174	17
α-helix	252-254	3
α-helix	263-267	5
α-helix	270-272	3
β-strand	284-290	7	182
β-strand	296-300	5	183
β-strand	307-312	6	183
β-strand	315-320	6	183
β-strand	327-328	2	182
β-strand	333-336	4	183
β-strand	349-351	3	184
β-strand	358-360	3	184
β-strand	367	1	185
β-strand	369-370	2	184
β-strand	371	1	186
β-strand	380	1	186
β-strand	385	1	185
β-strand	391	1	187
β-strand	395-397	3	188
β-strand	401-403	3	188
β-strand	405	1	188
β-strand	406	1	187
β-strand	410-415	6	188
β-strand	420-426	7	188
α-helix	427-428	2
β-strand	434-438	5	189
β-strand	441-445	5	189
β-strand	452	1	189
β-strand	453-455	3	190
β-strand	460-463	4	190
β-strand	471-476	6	191
β-strand	482-487	6	191
β-strand	493-496	4	191
β-strand	503-505	3	191
β-strand	513-518	6	192
β-strand	524-529	6	192
β-strand	533-538	6	192
β-strand	544-549	6	192
β-strand	556-559	4	182
β-strand	565-569	5	182
β-strand	574-579	6	182

Chains 6 and O: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	28-30	3	142
α-helix	39-41	3
β-strand	45-50	6	212
α-helix	51-58	8
α-helix	62-72	11
β-strand	75-79	5	212
β-strand	86-92	7	212
α-helix	95-143	49

Chain 7: 46 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	98-109	12
α-helix	120-129	10
β-strand	133	1	238
β-strand	136	1	238
β-strand	140-145	6	239
α-helix	151-163	13
β-strand	174-178	5	239
β-strand	187-188	2	240
α-helix	190-197	8
α-helix	202-210	9
α-helix	211-213	3
β-strand	216-220	5	239
α-helix	223-228	6
β-strand	244-245	2	240
α-helix	246-255	10
β-strand	264-269	6	239
α-helix	273-279	7
β-strand	286-289	4	239
α-helix	293-303	11
α-helix	310-317	8
α-helix	321-327	7
α-helix	330-345	16
α-helix	348-350	3
α-helix	357-372	16
α-helix	378-380	3
α-helix	381-400	20
α-helix	407-413	7
α-helix	417-424	8
β-strand	432	1	241
β-strand	439	1	241
α-helix	445-458	14
α-helix	465-467	3
α-helix	487-498	12
α-helix	501-511	11
α-helix	514-515	2
α-helix	519-531	13
α-helix	539-551	13
α-helix	555-561	7
β-strand	568-569	2	242
α-helix	575-587	13
β-strand	594-595	2	242
α-helix	601-603	3
α-helix	624-638	15
β-strand	644-646	3	242
α-helix	654-664	11
β-strand	673-675	3	242
α-helix	682-684	3
α-helix	685-694	10
β-strand	700-704	5	243
α-helix	710-721	12
β-strand	729-733	5	243
α-helix	739-750	12
β-strand	757-761	5	243
α-helix	767-778	12
β-strand	786-790	5	243
α-helix	796-806	11
β-strand	814-818	5	243
α-helix	824-835	12
β-strand	843-846	4	243
α-helix	853-865	13
β-strand	871-873	3	243
α-helix	881-892	12
β-strand	900-903	4	243
α-helix	911-922	12
β-strand	928-931	4	243
α-helix	937-950	14
β-strand	957-959	3	243
α-helix	970-979	10
β-strand	985-987	3	243
α-helix	995-1006	12
β-strand	1014-1016	3	243
α-helix	1019-1021	3
α-helix	1024-1036	13
β-strand	1041-1043	3	243

61 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
KH domain-containing protein 3	0, S	protein	440	Mus musculus	Q9CWU5 (AlphaFold model)
Inactive protein-arginine deiminase type-6	1, 2, 3, A, B, C, D, E, F, G, H, I, J, K, L, m, s, t, u, v, w, x, y, z	protein	682	Mus musculus	Q8K3V4 (AlphaFold model)
NACHT, LRR and PYD domains-containing protein 5	4, 7, M, P	protein	1163	Mus musculus	Q9R1M5 (AlphaFold model)
Transducin-like enhancer protein 6	5, 8, N, Q	protein	581	Mus musculus	Q9WVB3 (AlphaFold model)
Oocyte-expressed protein homolog	6, 9, O, R	protein	164	Mus musculus	Q9CWE6
Zinc finger BED domain-containing protein 3	AA, T	protein	228	Mus musculus	Q9D0L1
NLR family, pyrin domain containing 4F	AE, AF, X, Y	protein	937	Mus musculus	L7N1W9
NACHT, LRR and PYD domains-containing protein 14	AG, Z, n	protein	993	Mus musculus	Q6B966
E3 ubiquitin-protein ligase UHRF1	AH, a, o	protein	782	Mus musculus	Q8VDF2
Ubiquitin-conjugating enzyme E2 D3	AI, b, p	protein	147	Mus musculus	P61079
Tubulin alpha-1C chain	AJ, c, q	protein	449	Mus musculus	P68373
Tubulin beta-4B chain	AK, d, r	protein	445	Mus musculus	P68372

3 more molecules are not listed.

Sequence of entity 1 (0, S), FASTA

>9T67_1 KH domain-containing protein 3 (chains 0, S)
MASLKRFQTLVPLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGE
HIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAHYCRMKLMEIEALE
AGVERRRMAAHKAATQPAPVKVREAAPRPASVKVPETATQPAPVKVREAAPQPAPVQEVR
EAAPQQASVQEEVREAATEQAPVQEVREAATEQAPVQEVSEAATEQAPVQEVNEAATEQA
SVQAVREAATRPAPGKVRKAATQPAPVQVCQEATQLAPVKVREAATQPASGKVREAATQL
APVKVRKAATQLAPVKVHEAATQPAPGKVSDAATQSASVQVREAATQLSPVEATDTSQLA
QVKADEAFAQHTSGEAHQVANGQSPIEVCETATGQHSLDVSRALSQKCPEVFEWETQSCL
DGSYVIVQPPRDAWESFIIL

Sequence of entity 2 (1, 2, 3, A, B, C, D, E, F, G, H, I, J, K, L, m, s, t, u, v, w, x, y, z), FASTA

>9T67_2 Inactive protein-arginine deiminase type-6 (chains 1, 2, 3, A, B, C, D, E, F, G, H, I, J, K, L, m, s, t, u, v, w, x, y, z)
MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGK
EDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEA
DIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQ
MNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENR
RKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQ
MPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKT
VSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDY
PLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTND
KNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILAD
KSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARP
YFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIG
DVCASAIINRVPFAFKWWKMTP

Sequence of entity 3 (4, 7, M, P), FASTA

>9T67_3 NACHT, LRR and PYD domains-containing protein 5 (chains 4, 7, M, P)
MGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKES
KAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKDSKAILKARG
LEEEQKSESTMSPSENVSRAILKDSGSEEVEQASERKMTSPENDSKSIQKDQGPEQEQTS
ETLQSKEEDEVTEADKDNGGDLQDYKAHVIAKFDTSVDLHYDSPEMKLLSDAFKPYQKTF
QPHTIILHGRPGVGKSALARSIVLGWAQGKLFQKMSFVIFFSVREIKWTEKSSLAQLIAK
ECPDSWDLVTKIMSQPERLLFVIDGLDDMDSVLQHDDMTLSRDWKDEQPIYILMYSLLRK
ALLPQSFLIITTRNTGLEKLKSMVVSPLYILVEGLSASRRSQLVLENISNESDRIQVFHS
LIENHQLFDQCQAPSVCSLVCEALQLQKKLGKRCTLPCQTLTGLYATLVFHQLTLKRPSQ
SALSQEEQITLVGLCMMAAEGVWTMRSVFYDDDLKNYSLKESEILALFHMNILLQVGHNS
EQCYVFSHLSLQDFFAALYYVLEGLEEWNQHFCFIENQRSIMEVKRTDDTRLLGMKRFLF
GLMNKDILKTLEVLFEYPVIPTVEQKLQHWVSLIAQQVNGTSPMDTLDAFYCLFESQDEE
FVGGALKRFQEVWLLINQKMDLKVSSYCLKHCQNLKAIRVDIRDLLSVDNTLELCPVVTV
QETQCKPLLMEWWGNFCSVLGSLRNLKELDLGDSILSQRAMKILCLELRNQSCRIQKLTF
KSAEVVSGLKHLWKLLFSNQNLKYLNLGNTPMKDDDMKLACEALKHPKCSVETLRLDSCE
LTIIGYEMISTLLISTTRLKCLSLAKNRVGVKSMISLGNALSSSMCLLQKLILDNCGLTP
ASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECALQRLILNHCNIVDDAY
GFLAMRLANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQELELVDCQLTQNCCEDL
ACMITTTKHLKSLDLGNNALGDKGVITLCEGLKQSSSSLRRLGLGACKLTSNCCEALSLA
ISCNPHLNSLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGLWKQEYYARVRRQLEEVEFV
KPHVVIDGDWYASDEDDRNWWKN

Sequence of entity 4 (5, 8, N, Q), FASTA

>9T67_4 Transducin-like enhancer protein 6 (chains 5, 8, N, Q)
MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIE
RFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQH
PKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQE
HGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPET
QESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVA
VSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFA
GGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQE
IVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTE
DWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMP
TGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY

Sequence of entity 5 (6, 9, O, R), FASTA

>9T67_5 Oocyte-expressed protein homolog (chains 6, 9, O, R)
MASHTADADAKPDSDSQKLLNVLPVSLRLRTRPWWFPIQEVSNPLVLYMEAWVAERVIGT
DQAEISEIEWMCQALLTVDSVNSGNLAEITIFGQPSAQTRMKNILLNMAAWHKENELQRA
VKVKEVEEFLKIRASSILSKLSKKGLKLAGFPLPLEGRETQMES

Sequence of entity 6 (AA, T), FASTA

>9T67_6 Zinc finger BED domain-containing protein 3 (chains AA, T)
MKSKKPLKITMEDSRRLNDPAEQGGLCPAPVGPSYSEAWGYFHLDPAQPRHRMMSAWATC
RLCGLQVGGLPNFQMWTRALCQHLSDVHLPELKKSAAPSSPTTMPCPPPPSPTMAAEGDW
ARLLEQMGELAMRGSQRELELERREAALMQAELELERKRQALKQEAQSVEQERHQLQVER
EALSKWIKKQSPGAQVPEPPSPLPLLPKEDPDIHDNNSDNDMVTKVLL

Sequence of entity 7 (AE, AF, X, Y), FASTA

>9T67_7 NLR family, pyrin domain containing 4F (chains AE, AF, X, Y)
MASFISDFGLIWYLRELNKKEFMKFKDFLIQEILELKLKQVSSTKVKKASREDLANLLLK
CGENQAWDMTFRILQKINRKDLTERATGAIVGNPNLYRDHLKKKLTHDCPKKFNVRIQDF
IKETFIQNDYDAFENLLISKGTERKPHMVFLKGMAGVGKTLMLKNLMLAWSKGLVFQNKF
SYAFYFCCQDVKQLKTASLAELISREWPSPSAPIEEILSQPEKLLFIIDSLEGMEWDLTK
QESELCDDCMEKQPVSTLLSSLLRRKMLPESSLLLSTTPETFEKMEDRIQCTDVKTATAF
DERSMKIYFHRLFQDRKRAQEAFSLVRENKQLFTICQVPLLCWMVATCLKEEIEKGGDPV
SLCRRTTSLYTTHIFSLFIPQSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFGKEALRRN
GIFDSDIPTLLDIGMLGKIREFENSYIFLHPSVQEVCAAIFYMLKRHVEHPSQDVKNIET
VLFMFLKKVKTQWIFLGCFIFGLLQKSEQEKLGVFFGHRLSKNIHHKLYQCLETLSGNAE
LQEQIDGMRLFSCLFEMEDEAFLVKAMNCMQQINFVAKNYSDFIVAAYCLKHCSTLKKLS
FSTENVLNEGDQSYMEELLICWNNMCSVFVRSKDIQELRIKDTNFNEPAIRVLYESLKYP
SFTLNKLVANNVSFGDNHVLFELIQNSSLQYLDLSCSFLSHNEVKLLCDILNQAECNIEK
LMIAHCKLSPDDCKIFGSILMSSKSLKVLNLASNNLNQGISSLCKALCHPHCTLEYLVLS
NCSLSEQCWDYLSEVLRQNKTLSHLDISSNDLKDEGLKILCRSLILPYCVLESLCLSCCG
ITERGCQDLAEVLKNNQNLKYLHVSYNKLKDTGVMLLCDAIKHPNCHLKDLQLEACEITD
ASNEELCYAFMQCETLQTLNLMGNAFEVSRMVFFPRF

Sequence of entity 8 (AG, Z, n), FASTA

>9T67_8 NACHT, LRR and PYD domains-containing protein 14 (chains AG, Z, n)
MKTEDDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITP
KDQNLLQHIFDEDIQTSEAPQTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLN
GKEISQVKEKSFAQLISKHWPSSEGPIEQVLSKPSSLLFIIDSFDELDFSFEEPQFALCK
DWTQISPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSKNARMD
YIHHLLKDKAWATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQVEKGGRVEETCKTST
ALFTYYICSLFPRIPVGCVTLPNETLLRSLCKAAVEGIWTMKHVLYQQNLRKHELTREDI
LLFLDAKVLQQDTEYENCYMFTHLHVQEFFAALFYLLRENLEEQDYPSEPFENLYLLLES
NHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREELLACLEGLEKDDSSLSQL
RFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARA
DLKNMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLYESRLDESLMKILNEELS
HPKCKLQKLIFRAVDFLNGCQDFTFLASNKKVTHLDLKETDLGVNGLKTLCEALKCKGCK
LRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLCEVLENPNSSLER
LALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVL
RSCSFTPIGSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSC
VLTSKACGDLASVLVNNSNLWSLDLGHNILDDAGLNILCDALRNPNCHVQRLGLENCGLT
PGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALDKKEILKKK
IKKFLVDVRINNPHLVIGPECPNTESGCWWNYF

Sequence of entity 9 (AH, a, o), FASTA

>9T67_9 E3 ubiquitin-protein ligase UHRF1 (chains AH, a, o)
MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEEVFHVEPQLQRLFYRGKQMEDGHTLFD
YDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHSESDKSSTHGEGAAEADDK
TVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEPCSSSAVKTSEDDIMY
HVKYDDYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEIC
RKRQTRTARELYGNIRLLNDSQLNNCRIMFVDEVLMIELPKERRPLIASPSQPPPALRNT
GKSGPSCRFCKDDENKPCRKCACHVCGGREAPEKQLLCDECDMAFHLYCLKPPLTSVPPE
PEWYCPSCRTDSSEVVQAGEKLKESKKKAKMASATSSSRRDWGKGMACVGRTTECTIVPA
NHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDNGNY
FTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVV
RNMKGGKHSKYAPAEGNRYDGIYKVVKYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKD
RTRQLGLTMQYPEGYLEALANKEKSRKRPAKALEQGPSSSKTGKSKQKSTGPTLSSPRAS
KKSKLEPYTLSEQQANLIKEDKGNAKLWDDVLTSLQDGPYQIFLSKVKEAFQCICCQELV
FRPVTTVCQHNVCKDCLDRSFRAQVFSCPACRFELDHSSPTRVNQPLQTILNQLFPGYGS
GR

Sequence of entity 10 (AI, b, p), FASTA

>9T67_10 Ubiquitin-conjugating enzyme E2 D3 (chains AI, b, p)
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDRDKYNRISREWTQKYAM

Sequence of entity 11 (AJ, c, q), FASTA

>9T67_11 Tubulin alpha-1C chain (chains AJ, c, q)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSAEGDDEGEEY

Sequence of entity 12 (AK, d, r), FASTA

>9T67_12 Tubulin beta-4B chain (chains AK, d, r)
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Primary citation

In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies. Singh, K., Harasimov, K., Niakan, K.K. et al. EMBO J (2026). DOI 10.1038/s44318-026-00895-w · PubMed

Other PDB entries of the same protein (UniProt Q9CWU5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3V69 2.2 Å, Filia-N crystal structure
24MC 3.4 Å, Structure of oocyte cytoplasmic lattices
12DL 3.5 Å, Native structure of the cytoplasmic lattice (CPL) asymmetric unit from mouse MII eggs
9XRL 3.74 Å, Structure of mouse cytoplasmic lattice (CPL) repeating unit
9SFP 4.2 Å, Native cytoplasmic lattices from mouse oocytes
9W2M 4.2 Å, Cryo-EM structure of the Cytoplasmic lattice(CPL) from mouse oocyte
9T63 4.7 Å, Asymmetric unit of a cytoplasmic lattice filament repeat unit
9T66 5.3 Å, Complex linking two repeat units of a cytoplasmic lattice filament
9T64 7.3 Å, Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex
9T68 8.0 Å, Composite structure of the repeat unit of cytoplasmic lattice filament

Browse structure collections

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