Fanconi anemia core complex-associated protein 20 (FAAP20) is a 180-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6NZ36.
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The mean pLDDT of this model is 65.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 36% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1
Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts (via UBZ2-type zinc finger) with REV1; this interaction contributes to the stable association of the two proteins in nuclear foci in response to replication stress. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3WWQ | X-ray | 1.9 Å | C/F/I/L=142-180 |
| 2MUQ | NMR | A=140-180 | |
| 2MUR | NMR | A=140-180 |
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