von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide. Determined by X-ray diffraction at 1.73 Å resolution. Released 14 Nov 2012.
Explore 4AJY in 3D Show helices and sheets RCSB PDB PDBe
4AJY contains 21 α-helices and 29 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-9 | 8 | 1 |
| β-strand | 10 | 1 | 2 |
| β-strand | 12-19 | 8 | 1 |
| β-strand | 23 | 1 | 3 |
| α-helix | 24-35 | 12 | |
| α-helix | 39-41 | 3 | |
| β-strand | 42-46 | 5 | 1 |
| β-strand | 49-50 | 2 | 1 |
| α-helix | 51-52 | 2 | |
| β-strand | 56 | 1 | 3 |
| α-helix | 64-66 | 3 | |
| β-strand | 68 | 1 | 4 |
| β-strand | 71 | 1 | 4 |
| α-helix | 72 | 1 | |
| β-strand | 73-79 | 7 | 1 |
| α-helix | 86-88 | 3 | |
| β-strand | 90 | 1 | 2 |
| α-helix | 98-100 | 3 | |
| α-helix | 101-103 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 18-22 | 5 | 1 |
| β-strand | 28-32 | 5 | 1 |
| α-helix | 33-36 | 4 | |
| α-helix | 40-46 | 7 | |
| β-strand | 59-61 | 3 | 1 |
| α-helix | 67-83 | 17 | |
| α-helix | 89-94 | 6 | |
| α-helix | 97-99 | 3 | |
| α-helix | 100-110 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 565 | 1 | 5 |
| β-strand | 572-573 | 2 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 71-78 | 8 | 5 |
| α-helix | 83 | 1 | |
| β-strand | 84-89 | 6 | 6 |
| β-strand | 95-97 | 3 | 6 |
| β-strand | 101 | 1 | 6 |
| β-strand | 105-112 | 8 | 5 |
| β-strand | 116-121 | 6 | 6 |
| β-strand | 127 | 1 | 6 |
| β-strand | 129-130 | 2 | 5 |
| β-strand | 133 | 1 | 5 |
| β-strand | 136 | 1 | 6 |
| α-helix | 140-141 | 2 | |
| β-strand | 142 | 1 | 7 |
| β-strand | 145 | 1 | 7 |
| α-helix | 146 | 1 | |
| β-strand | 147-152 | 6 | 5 |
| α-helix | 158-169 | 12 | |
| α-helix | 172-177 | 6 | |
| α-helix | 183-189 | 7 | |
| α-helix | 194-206 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transcription elongation factor B polypeptide 2 | B | protein | 118 | HOMO SAPIENS | Q15370 (AlphaFold model) |
| Transcription elongation factor B polypeptide 1 | C | protein | 97 | HOMO SAPIENS | Q15369 (AlphaFold model) |
| Hypoxia-inducible factor 1-alpha | H | protein | 19 | HOMO SAPIENS | Q16665 (AlphaFold model) |
| Von hippel-lindau disease tumor suppressor | V | protein | 163 | HOMO SAPIENS | P40337 (AlphaFold model) |
>4AJY_1 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 (chains B) MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
>4AJY_2 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 (chains C) MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCM YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
>4AJY_3 HYPOXIA-INDUCIBLE FACTOR 1-ALPHA (chains H) DEALAPYIPMDDDFQLRSF
>4AJY_4 VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR (chains V) GSHMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH SYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLV KPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Van Molle, I., Thomann, A., Buckley, D.L. et al. Chem Biol (2012) 19:1300. DOI 10.1016/J.CHEMBIOL.2012.08.015 · PubMed
Other PDB entries of the same protein (UniProt Q15370 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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