4APO: AIP TPR domain

AIP TPR domain in complex with human Tomm20 peptide. Determined by X-ray diffraction at 1.9 Å resolution. Released 23 Jan 2013.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 2,997
Mol. weight: 39.94 kDa
Released: 23 Jan 2013

Explore 4APO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4APO contains 18 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	173-176	4
α-helix	178-192	15
α-helix	195-213	19
α-helix	221-243	23
α-helix	248-260	13
α-helix	265-277	13
α-helix	281-294	14
α-helix	296-298	3
α-helix	299-311	13

Chain B: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	175-178	4
α-helix	179-192	14
α-helix	195-214	20
α-helix	221-243	23
α-helix	248-260	13
α-helix	265-277	13
α-helix	281-294	14
α-helix	296-298	3
α-helix	299-324	26

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ah receptor-interacting protein	A, B	protein	165	HOMO SAPIENS	O00170 (AlphaFold model)
Mitochondrial import receptor subunit TOM20 homolog	D, E	protein	6	HOMO SAPIENS	Q15388 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4APO_1 AH RECEPTOR-INTERACTING PROTEIN (chains A, B)
DPWAMTAEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQ
LDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQ
ADFAKVLELDPALAPVVSRELQALEARIRQKDEEDKARFRGIFSH

Sequence of entity 2 (D, E), FASTA

>4APO_2 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG (chains D, E)
AEDDVE

Primary citation

Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition. Morgan, R.M., Hernandez-Ramirez, L.C., Trivellin, G. et al. PLoS One (2012) 7:53339. DOI 10.1371/JOURNAL.PONE.0053339 · PubMed

Other PDB entries of the same protein (UniProt O00170 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4AIF 2.01 Å, AIP TPR domain in complex with human Hsp90 peptide
8QMO 2.76 Å, Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex
7ZUB 2.85 Å, Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
2LKN Solution structure of the PPIase domain of human aryl-hydrocarbon receptor-interacting…

Browse structure collections

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