4B4N: Gag protein

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. Determined by X-ray diffraction at 1.81 Å resolution. Released 19 Sept 2012.

Method: X-ray diffraction
Resolution: 1.81 Å
Organisms: HUMAN IMMUNODEFICIENCY VIRUS 1, HOMO SAPIENS
Chains: 2
Atoms: 1,285
Mol. weight: 17.76 kDa
Released: 19 Sept 2012

Explore 4B4N in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4B4N contains 10 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	1
β-strand	10-12	3	1
α-helix	14-16	3
α-helix	17-30	14
α-helix	36-43	8
α-helix	49-56	8
α-helix	63-82	20
α-helix	98-100	3
α-helix	101-104	4
α-helix	111-118	8
α-helix	126-144	19

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	332-334	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Gag protein	A	protein	146	HUMAN IMMUNODEFICIENCY VIRUS 1	A9PKC6
Cleavage and polyadenylation specificity factor subunit 6	B	protein	15	HOMO SAPIENS	Q16630 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4B4N_1 GAG PROTEIN (chains A)
PIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVG
GHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTH
NPPIPVGEIYKRWIILGLNKIVRMYS

Sequence of entity 2 (B), FASTA

>4B4N_2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 (chains B)
PVLFPGQPFGQPPLG

Primary citation

Cpsf6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication. Price, A.J., Fletcher, A.J., Schaller, T. et al. PLoS Pathog (2012) 8:2896. DOI 10.1371/JOURNAL.PPAT.1002896 · PubMed

Other PDB entries of the same protein (UniProt A9PKC6), best resolution first:

5HGK 1.76 Å, HIV-1 CA N-terminal domain, open conformation
4INB 1.8 Å, Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With…

Browse structure collections

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