Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) is a 551-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16630.
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The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex…
Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7 (PubMed:14561889, PubMed:20695905, PubMed:23187700, PubMed:8626397, PubMed:9659921). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA…
Nucleus, Nucleus, nucleoplasm, Nucleus speckle, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4B4N | X-ray | 1.81 Å | B=276-290 |
| 4U0A | X-ray | 2.05 Å | B=276-290 |
| 6AY9 | X-ray | 2.5 Å | B=276-287 |
| 4WYM | X-ray | 2.6 Å | M/N/O/P/Q/R/S/T/U/V/W=276-290 |
| 3P5T | X-ray | 2.7 Å | L/M/N/O/P/Q=80-161 |
| 6GX9 | X-ray | 2.7 Å | C/D=481-550 |
| 4U0B | X-ray | 2.8 Å | M/N/O/P/Q/R/S/T/U/V/W/X=276-290 |
| 7SNQ | X-ray | 2.81 Å | M/N/O/P/Q/R/S/T/U/V/W/X=276-290 |
| 3P6Y | X-ray | 2.9 Å | C/D/G/H/K/L/O/P=80-161 |
| 3Q2S | X-ray | 2.9 Å | C/D=13-235 |
| 7ZUD | X-ray | 2.93 Å | M=276-288 |
| 3Q2T | X-ray | 3.06 Å | C/D=13-235 |
| 9CNV | EM | 3.16 Å | B=276-290 |
| 8GDV | X-ray | 3.3 Å | M/N/O/P/Q/R=276-290 |
| 8CL1 | EM | 3.35 Å | B=276-290 |
| 8EJL | EM | 3.9 Å | Y/Z=276-290 |
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