4F25: Second RRM domain of human PABPC1 at pH 6.0

Crystal structure of the second RRM domain of human PABPC1 at pH 6.0. Determined by X-ray diffraction at 1.9 Å resolution. Released 8 Aug 2012.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 1
Atoms: 700
Mol. weight: 12.68 kDa
Released: 8 Aug 2012

Explore 4F25 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4F25 contains 5 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	100-104	5	1
α-helix	112-119	8
α-helix	120-122	3
β-strand	125-133	9	1
β-strand	136-145	10	1
α-helix	148-158	11
β-strand	162-163	2	2
β-strand	166-167	2	2
α-helix	168	1
β-strand	169-172	4	1
α-helix	175-177	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Polyadenylate-binding protein 1	A	protein	115	Homo sapiens	P11940 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4F25_1 Polyadenylate-binding protein 1 (chains A)
GPLGSGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAER
AIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGPGSTRAAAS

Primary citation

Interdomain Allostery Promotes Assembly of the Poly(A) mRNA Complex with PABP and eIF4G. Safaee, N., Kozlov, G., Noronha, A.M. et al. Mol Cell (2012) 48:375-386. DOI 10.1016/j.molcel.2012.09.001 · PubMed

Other PDB entries of the same protein (UniProt P11940 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KUJ 1.4 Å, Crystal structure of C-terminal domain of PABPC1 in complex with binding region of eRF3a
3KUS 1.4 Å, Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the…
2X04 1.49 Å, Crystal structure of the PABC-TNRC6C complex
3KTP 1.5 Å, Structural basis of GW182 recognition by poly(A)-binding protein
3KUT 1.5 Å, Crystal structure of the MLLE domain of poly(A)-binding protein in complex with the…
3KTR 1.7 Å, Structural basis of ataxin-2 recognition by poly(A)-binding protein
3PTH 1.7 Å, The PABC1 MLLE domain bound to the variant PAM2 motif of LARP4B
3PKN 1.8 Å, Crystal structure of MLLE domain of poly(A) binding protein in complex with PAM2 motif…
5DX1 1.93 Å, Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455)
7BN3 1.93 Å, Crystal structure of C-terminal domain of PABPC1 in complex with Nucleoprotein from…
5DX8 1.94 Å, Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455)
4F02 2.0 Å, Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and…

Browse structure collections

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