4HEX: A novel conformation of calmodulin

A novel conformation of calmodulin. Determined by X-ray diffraction at 2.0 Å resolution. Released 6 Mar 2013.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Mus musculus
Chains: 2
Atoms: 2,289
Mol. weight: 36.18 kDa
Ligands: CA, ZN
Released: 6 Mar 2013

Explore 4HEX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4HEX contains 16 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	10-20	11
β-strand	27-28	2	1
α-helix	30-39	10
α-helix	46-54	9
β-strand	64-65	2	1
α-helix	66-73	8
α-helix	78-93	16
β-strand	100-101	2	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-142	4

Chain B: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	9-20	12
β-strand	27-28	2	3
α-helix	30-39	10
α-helix	46-54	9
β-strand	64-65	2	3
α-helix	66-73	8
α-helix	78-93	16
β-strand	100-101	2	4
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	4
α-helix	139-145	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B	protein	156	Mus musculus	P0DP26 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4HEX_1 Calmodulin (chains A, B)
MHHHHHHMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMI
NEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNL
GEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4
ZN	Zinc ion	Zn	6

Primary citation

A novel trans conformation of ligand-free calmodulin. Kumar, V., Chichili, V.P.R., Tang, X. et al. PLoS One (2013) 8:e54834-e54834. DOI 10.1371/journal.pone.0054834 · PubMed

Other PDB entries of the same protein (UniProt P0DP26 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7CQP 1.9 Å, Complex of TRPC4 and Calmodulin_Nlobe
3WFN 1.95 Å, Crystal Structure of Nav1.6 IQ motif in complex with apo-CaM
2IX7 2.5 Å, Structure of apo-calmodulin bound to unconventional myosin V
4ZLK 2.5 Å, Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin
4E53 2.69 Å, Calmodulin and Nm peptide complex
4E50 2.7 Å, Calmodulin and Ng peptide complex
9CFV 2.7 Å, Cryo-EM structure of delta-NTR myosin-1c bound to F-actin
9CFX 2.7 Å, Cryo-EM structure of myosin-1c bound to F-actin in the Rigor state
9CFU 2.8 Å, Cryo-EM structure of myosin-1c bound to F-actin in the ADP-A state
9CFW 3.0 Å, Cryo-EM structure of myosin-1c bound to F-actin in the ADP-B state
8PB1 3.5 Å, Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling…
8W41 3.54 Å, Cryo-EM structure of Myosin VI in the autoinhibited state

Browse structure collections

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